1,6-炔环异构化的光氧化还原/钴协同催化。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-10 DOI:10.1021/acs.orglett.5c03418

Zhongjian Du, Chenlei Ji, Zhiwei Jiang and Yang’en You*,

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引用次数: 0

摘要

在钴配位的可见光催化下，研究了1,6-炔的高区域选择性和立体选择性环异构化反应。该方法可以使用市售的钴催化剂、配体和试剂，高效地合成具有优异立体选择性的各种跳过的1,4-二烯产物。值得注意的是，该反应在温和条件下表现出显著的区域选择性（>20:1）、立体选择性（Z/E >20:1）和高收率（58-92%），同时具有广泛的底物范围和良好的官能团耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photoredox/Cobalt Cooperative Catalysis for Cycloisomerization of 1,6-Enynes

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Photoredox/Cobalt Cooperative Catalysis for Cycloisomerization of 1,6-Enynes

Under visible-light photocatalysis facilitated by cobalt coordination, a highly regio- and stereoselective cycloisomerization reaction of 1,6-enynes has been developed. This method enables the efficient synthesis of various skipped 1,4-diene products with excellent stereoselectivity, using commercially available cobalt catalysts, ligands, and reagents. Notably, the reaction exhibits remarkable regioselectivity (>20:1), stereoselectivity (Z/E > 20:1), and high yields (58–92%) under mild conditions, along with a broad substrate scope and good functional group tolerance.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.