对儿童淋巴细胞恶性肿瘤的生殖系易感性的见解

IF 13.4 1区 医学 Q1 HEMATOLOGY
Roshina Thapa, Kim E. Nichols, Richa Sharma
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引用次数: 0

摘要

造血恶性肿瘤(HM)是儿童癌症最常见的形式,淋巴细胞恶性肿瘤是儿童的主要亚型。大多数淋巴细胞恶性肿瘤被认为是零星发生的,环境、感染和炎症触发因素影响肿瘤发生的方式尚不完全清楚。随着越来越多的癌症儿童采用生殖系基因检测,淋巴细胞恶性肿瘤的遗传易感性现在被认为是临床护理和研究的一个重要方面。对淋巴细胞发育(包括细胞分化、DNA重组、DNA损伤的识别和修复、细胞凋亡、RNA加工和细胞内信号传导)至关重要的基因的致病变异都汇聚在淋巴细胞恶性肿瘤的风险增加上。在此,我们回顾了几种遗传易感性的淋巴细胞恶性肿瘤的重点是潜在的生物学缺陷,以及相关的肿瘤和非肿瘤的表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Insights into germline predisposition to pediatric lymphoid malignancies

Insights into germline predisposition to pediatric lymphoid malignancies

Hematopoietic malignancies (HM) represent the most common form of pediatric cancer with lymphoid malignancies being the predominant subtype in kids. The majority of lymphoid malignancies are proposed to occur sporadically with environmental, infectious and inflammatory triggers impacting oncogenesis in ways that are not yet fully understood. With the increased adoption of germline genetic testing in children with cancer, genetic predisposition to lymphoid malignancies is now recognized as an important aspect of clinical care and research. Pathogenic variants in genes important for lymphocyte development, including cell differentiation, DNA recombination, recognition and repair of DNA damage, apoptosis, RNA processing, and intracellular signaling all converge on an increased risk for lymphoid malignancies. Herein, we review several genetic predispositions to lymphoid malignancies with a focus on the underlying biological defect, as well as the associated oncologic and non-oncologic manifestations.

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来源期刊
Leukemia
Leukemia 医学-血液学
CiteScore
18.10
自引率
3.50%
发文量
270
审稿时长
3-6 weeks
期刊介绍: Title: Leukemia Journal Overview: Publishes high-quality, peer-reviewed research Covers all aspects of research and treatment of leukemia and allied diseases Includes studies of normal hemopoiesis due to comparative relevance Topics of Interest: Oncogenes Growth factors Stem cells Leukemia genomics Cell cycle Signal transduction Molecular targets for therapy And more Content Types: Original research articles Reviews Letters Correspondence Comments elaborating on significant advances and covering topical issues
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