家族史是未调查的消化不良和慢性便秘的主要危险因素:一项基于罗马iv的日本大学生研究

IF 3.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Digestion Pub Date : 2025-09-08 DOI:10.1159/000548363
Nhu Thi Hanh Vu, Duc Trong Quach, Mai Ngoc Luu, Shunsuke Miyauchi, Naoki Ishiuchi, Doan Thi Nha Nguyen, Atsuo Yoshino, Yoshie Miyake, Yuri Okamoto, Shiro Oka, Toru Hiyama
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引用次数: 0

摘要

背景未调查的消化不良(UD)和慢性便秘(CC)是肠脑相互作用(DGBI)的常见疾病。然而,有限的研究评估了他们在年轻人中的风险因素,特别是家族史的影响。本研究以日本大学生的家族史为研究对象,探讨UD和CC的相关因素。方法在广岛大学进行横断面研究。UD和CC的诊断采用Rome IV标准。结果在10,500名参加年度健康体检的个体中,7,496人回答了基于网络的问卷,5,386人完成了问卷。参与者的平均年龄为21.1±4.1岁,男女比例为1:1.17。UD和CC的患病率分别为7.3%和13.7%。家族史与UD(比值比[OR]: 4.29; 95%可信区间[CI]: 3.17-5.79)和CC(比值比:2.77;95% CI: 2.31-3.31)相关。抑郁和缺乏运动是共同的相关因素。饮酒(OR = 2.36; 95% CI: 1.15-4.83)和吸烟(OR = 1.59; 95% CI: 1.02-2.49)被确定为UD的相关因素,而女性(OR = 2.00; 95% CI: 1.69-2.36)和睡眠时间短(OR = 1.28; 95% CI: 1.09-1.50)与CC相关。结论家族史是UD和CC的主要相关因素,与UD的相关性相对较强。我们的发现强调了在未来年轻人UD和CC的预防和干预策略中考虑家族因素的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Family History as a Dominant Risk Factor for Uninvestigated Dyspepsia and Chronic Constipation: A Rome IV-Based Study among Japanese University Students.

Background Uninvestigated dyspepsia (UD) and chronic constipation (CC) are common disorders of gut-brain interaction (DGBI). However, limited research has assessed their risk factors in young adults, particularly the influence of family history. This study investigated the associated factors for UD and CC, focusing on family history among Japanese university students. Methods A cross-sectional study was conducted at Hiroshima University. UD and CC were diagnosed using the Rome IV criteria. Multivariate logistic regression was performed to identify associated factors of UD and CC. Results Among 10,500 individuals participating in the annual health checkup, 7,496 responded to the web-based questionnaire, and 5,386 completed it. The mean age of the participants was 21.1 ± 4.1 years, with a male-to-female ratio of 1:1.17. The prevalence of UD and CC was 7.3% and 13.7%, respectively. Family history was associated with both UD (odds ratio [OR]: 4.29; 95% confidence interval [CI]: 3.17-5.79) and CC (OR: 2.77; 95% CI: 2.31-3.31). Depression and physical inactivity were shared associated factors. Alcohol consumption (OR = 2.36; 95% CI: 1.15-4.83) and smoking (OR = 1.59; 95% CI: 1.02-2.49) were identified as associated factors for UD, while female sex (OR = 2.00; 95% CI: 1.69-2.36) and short sleep duration (OR = 1.28; 95% CI: 1.09-1.50) were associated with CC. Conclusions Family history was found to be a predominant factor associated with both UD and CC, with a relatively stronger association for UD. Our finding highlights the need to consider familial factors in future prevention and intervention strategies for UD and CC in young adults.

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来源期刊
Digestion
Digestion 医学-胃肠肝病学
CiteScore
7.90
自引率
0.00%
发文量
39
审稿时长
6-12 weeks
期刊介绍: ''Digestion'' concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal''s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology.
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