Note: An Integrated Miniature Time-of-Flight Mass Spectrometer System with 3D Printing Assisted Design of Versatile Pocket-Size Laser-Induced Acoustic Desorption Source

An integrated miniature time-of-flight mass spectrometer (TOF-MS) system coupled with a pocket-size 3D-printed laser-induced acoustic desorption (LIAD) source is described. This 3D-printed LIAD source utilizes only a miniature deceleration motor to achieve two-dimensional motion of the target surface, simplifying the source structure and improving the long-term stability of mass spectrometry measurements. It has been successfully applied to analyze the model molecule creatinine and ingredients in an energy beverage (Red Bull), where main natural nutrients were clearly identified. By adjusting the 3D printing parameters, the source can be readily adapted to various application scenarios requiring different sizes. This work provides a simple and efficient 3D-printed source injection strategy for subsequent investigations in molecular reaction dynamics.