一种新型的直接-间接双层平板探测器用于对比增强乳房成像:实验评估

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2025-09-10 DOI:10.1002/mp.18108
Xiaoyu Duan, Hailiang Huang, Salman M. Arnab, Yves Chevalier, Luc Laperrière, Adrian Howansky, Wei Zhao
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引用次数: 0

摘要

背景在数字乳腺造影(CEDM)和数字乳腺造影(CEDBT)中,注射碘造影剂后可获得低能(LE)和高能(HE)图像。然后应用加权减法生成双能(DE)图像,其中正常乳腺组织被抑制,碘化物体被增强。目前,临床系统采用双镜头(DS)方法,其中LE和HE图像通过两次单独曝光获得。然而,患者在这些暴露之间的移动会导致在重组的DE图像中出现残留的乳房组织结构,从而降低碘化病变的可见性。为了解决这个问题,我们提出了一种直接间接双层平板检测器(DI-DLFPD),它通过同时获取LE和HE图像来消除患者的运动伪影。本研究旨在:(1)利用第一代原型DI-DLFPD对CEDM和CEDBT成像进行实验验证;(2)将病变显著性与DS方法获得的图像进行比较;(3)基于乳腺厚度对DI-DLFPD的k边滤波器进行优化。方法分别使用DI-DLFPD和传统DS单层探测器在相当剂量水平下获取CEDM和CEDBT图像,评估图像质量和碘靶显著性。优点图(FOM)定义为信噪比(SDNR)的平方除以平均腺体剂量。根据不同的乳房厚度,对DI-DLFPD k边滤波器的选择进行了评估。结果通过消除患者运动伪影,与受患者运动影响的DS图像相比,DI-DLFPD图像在碘物体FOM方面表现出显著改善(~ 233%)。碘的定量准确度也得到了提高。结果表明,对于平均乳房厚度(4 cm)使用银过滤器,对于较厚的乳房(8 cm)使用锡过滤器,可以达到DI-DLFPD的最佳碘SDNR。本研究提供了用于CEDM和CEDBT的第一代原型DI-DLFPD的实验结果。推荐了一种实用的策略,其中基于压缩乳房厚度优化了DI-DLFPD的x射线滤光片。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A novel direct-indirect dual-layer flat-panel detector for contrast-enhanced breast imaging: Experimental assessment

A novel direct-indirect dual-layer flat-panel detector for contrast-enhanced breast imaging: Experimental assessment

A novel direct-indirect dual-layer flat-panel detector for contrast-enhanced breast imaging: Experimental assessment

Background

In contrast-enhanced digital mammography (CEDM) and contrast-enhanced digital breast tomosynthesis (CEDBT), low-energy (LE) and high-energy (HE) images are acquired after injection of iodine contrast agent. Weighted subtraction is then applied to generate dual-energy (DE) images, where normal breast tissues are suppressed, leaving iodinated objects enhanced. Currently, clinical systems employ a dual-shot (DS) method, where LE and HE images are acquired with two separate exposures. However, patient motion between these exposures can cause residual breast tissue structure to appear in the recombined DE images, reducing the visibility of iodinated lesions. To address this issue, we propose a direct-indirect dual-layer flat-panel detector (DI-DLFPD), which eliminates patient motion artifact by acquiring LE and HE images simultaneously.

Purpose

This study aims to: (1) experimentally validate CEDM and CEDBT imaging using a first-generation prototype DI-DLFPD, (2) compare lesion conspicuity with images obtained using the DS method, (3) optimize the k-edge filter for the DI-DLFPD based on breast thickness.

Methods

CEDM and CEDBT images were acquired using both the prototype DI-DLFPD and a conventional DS single-layer detector at comparable dose levels to evaluate image quality and iodine target conspicuity. The figure of merit (FOM) was defined as the square of signal difference to noise ratio (SDNR) divided by the mean glandular dose. The selection of k-edge filter for DI-DLFPD was assessed based on varying breast thickness.

Results

By eliminating patient motion artifacts, DI-DLFPD images exhibit a significant improvement (∼233%) in iodine object FOM compared to DS images affected by patient motion. Iodine quantification accuracy was also improved. The results suggest using a sliver filter for average breast thickness (4 cm) and a Tin filter for thicker breasts (8 cm) to achieve optimal iodine SDNR for DI-DLFPD.

Conclusions

This study presents experimental results from the first-generation prototype DI-DLFPD for CEDM and CEDBT. A practical strategy was recommended, where the x-ray filter for DI-DLFPD was optimized based on the compressed breast thickness.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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