高分辨率双端读出PET探测器基于0.5 mm间距LYSO阵列与各种反射器

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2025-09-10 DOI:10.1002/mp.18103
Jiahao Xie, Haibo Wang, Junwei Du
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引用次数: 0

摘要

高分辨率和高灵敏度的小动物正电子发射断层扫描(PET)扫描仪是临床前研究中必不可少的非侵入性功能成像工具。为了开发具有均匀和高空间分辨率的小动物PET扫描仪,能够提供良好的相互作用深度(DOI)信息的PET探测器至关重要。基于细间距氧化硅酸镥钇(LYSO)阵列的双端读出探测器是一种很有前途的方法,其中晶间反射器的选择对探测器的性能有很大影响。东丽E60厚度为50 μ m,作为晶体间反射器用于制造双端读出探测器中使用的LYSO阵列已有二十多年的历史。然而,东丽E60最近已经停产。本研究旨在确定东丽E60反射器的最佳替代品,促进高分辨率和高灵敏度小动物PET扫描仪双端读出检测器的持续发展。方法构建5个基于10 × 10 LYSO阵列的双端读出检测器,并对其进行评价。这些LYSO阵列采用不同的反射器:东丽E60的厚度为50µm,硫酸钡(BaSO4)的厚度为80µm,东丽E20的厚度为40、52和76µm。所有LYSO阵列的间距均为0.5 mm,厚度为20 mm。两个线性梯度硅光电倍增管(LG-SiPMs)作为光电探测器。综合比较了五种探测器在晶体识别能力、能量分辨率、符合时序分辨率(CTR)、DOI分辨率等方面的性能。结果 在五个反射器,探测器基于LYSO数组与52µm厚东丽E20反射表现出最好的水晶识别能力和实现了能量分辨率20.2±3.8%,DOI分辨率为2.07±0.48毫米,和882±38 ps的CTR。相反,基于LYSO阵列探测器的50µm厚东丽E60反射显示22.0±3.3%的能量分辨率,DOI分辨率为1.88±0.25毫米,结论厚度为52 μ m的东丽E20反射器可以替代已停产的厚度为50 μ m的东丽E60反射器。它适用于制造用于双端读出检测器的精细倾斜和厚LYSO阵列,以开发高分辨率和高灵敏度的小动物PET扫描仪。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

High-resolution dual-ended readout PET detectors based on 0.5 mm pitch LYSO arrays with various reflectors

High-resolution dual-ended readout PET detectors based on 0.5 mm pitch LYSO arrays with various reflectors

High-resolution dual-ended readout PET detectors based on 0.5 mm pitch LYSO arrays with various reflectors

Background

High-resolution and high-sensitivity small-animal positron emission tomography (PET) scanners are essential non-invasive functional imaging tools in preclinical research. To develop small-animal PET scanners with uniform and high spatial resolution across the field-of-view, PET detectors capable of providing good depth-of-interaction (DOI) information are critical. Dual-ended readout detectors based on lutetium–yttrium oxyorthosilicate (LYSO) arrays with fine pitch represent a promising approach, wherein the choice of inter-crystal reflector significantly impacts the detector performance. Toray E60, with a 50 µm thickness, has been used for over two decades as an inter-crystal reflector for fabricating LYSO arrays used in dual-ended readout detectors. However, the Toray E60 has recently been discontinued.

Purpose

This study aims to identify an optimal alternative to the Toray E60 reflector, facilitating the continued development of dual-ended readout detectors for high-resolution and high-sensitivity small-animal PET scanners.

Methods

Five dual-ended readout detectors based on 10 × 10 LYSO arrays were constructed and evaluated. These LYSO arrays employed different reflectors: Toray E60 with 50 µm thickness, Barium sulfate (BaSO4) with 80 µm thickness, and Toray E20 with thicknesses of 40, 52, and 76 µm. All LYSO arrays featured the same pitch of 0.5 mm and thickness of 20 mm. Two linearly-graded silicon photomultipliers (LG-SiPMs) served as photodetectors. The performance of the five detectors in terms of crystal identification ability, energy resolution, coincidence timing resolution (CTR), and DOI resolution was comprehensively compared.

Results

Among the five reflectors, the detector based on the LYSO array with the 52 µm thick Toray E20 reflector exhibited the best crystal identification ability and achieved an energy resolution of 20.2 ± 3.8%, a DOI resolution of 2.07 ± 0.48 mm, and a CTR of 882 ± 38 ps. Conversely, the detector based on the LYSO array with the 50 µm thick Toray E60 reflector showed an energy resolution of 22.0 ± 3.3%, a DOI resolution of 1.88 ± 0.25 mm, and a CTR of 833 ± 32 ps.

Conclusions

The Toray E20 reflector with a thickness of 52 µm represents a viable alternative to the discontinued Toray E60 with a 50 µm thickness. It is suitable for fabricating finely pitched and thick LYSO arrays used in dual-ended readout detectors to develop high-resolution and high-sensitivity small-animal PET scanners.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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