一种用于导管射频消融非均质病变的热致变色组织模拟模型

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2025-09-10 DOI:10.1002/mp.18112
Ruizhe Hou, Quanshu Han, Jincheng Zou, Shiqing Zhao, Aili Zhang
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引用次数: 0

摘要

在基于导管的射频消融(RFA)中,能量被传递到异质薄壁组织以诱导治疗加热。组织内容物的电学和力学特性的变化对结果有很大的影响。本研究的目的是建立能够复制组织异质性和可视化消融区域的模型,以进行有效的评估和优化。方法采用去离子水、丙烯酰胺水溶液(Acr/Bis)、热致变色微胶囊粉、Tris-HCl缓冲液、过硫酸铵溶液和N,N,N‘,N’-四亚甲基乙二胺,制备可调热致变色幻体配方。对不同配方的变色温度阈值、电导率和弹性模量进行了表征。提出了一种基于浓度-性能回归模型的双参数反设计方法,以同时匹配组织的电学和力学性能,并通过对模型的RFA实验进行了验证。结果在60°C时,幻像呈现出由靛蓝到深粉红色的立即且不可逆的颜色变化,清晰地描绘了消融边缘。电导率范围为0.1892 ~ 0.5958 S/m,弹性模量范围为6.70 ~ 138 kPa,有效地涵盖了不同病变组织的特征性质。在模拟猪心肌和鸡胸肉的模型上进行的RFA实验与离体实验结果一致。与均匀模型相比,模拟动脉粥样硬化结构的异质幻影消融显示出显著差异。开发了一种可调的热致变色模体配方,在60°C下表现出精确的颜色变化,同时复制异质组织的电学和力学特性,从而可以直接可视化烧蚀边界。该假体为评估临床相关复杂组织中基于导管的RFA提供了一个强大的平台,支持个性化和优化治疗策略的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A thermochromic tissue-mimicking phantom for catheter-based radiofrequency ablation of heterogenous lesions

A thermochromic tissue-mimicking phantom for catheter-based radiofrequency ablation of heterogenous lesions

A thermochromic tissue-mimicking phantom for catheter-based radiofrequency ablation of heterogenous lesions

Background

In catheter-based radiofrequency ablation (RFA), energy is delivered to heterogeneous thin-walled tissues to induce therapeutic heating. Variations in electrical and mechanical properties of tissue contents have a great effect on outcomes.

Purpose

The objective of this study is to develop models that replicate tissue heterogeneity and visualize ablation zones for effective evaluation and optimization.

Methods

A tunable thermochromic phantom formulation was developed, consisting of deionized water, acrylamide aqueous solution (Acr/Bis), thermochromic microcapsule powder, Tris-HCl buffer, ammonium persulfate solution, and N,N,N',N'-tetramethylethylenediamine. The color-change temperature threshold, electrical conductivity, and elastic modulus were characterized with different formulation compositions. A dual-parameter inverse design method based on concentration-property regression models was proposed to match the electrical and mechanical properties of tissues simultaneously, which was validated through RFA experiments on phantoms.

Results

The phantoms exhibited an immediate and irreversible color change from indigo to deep pink at 60°C, clearly delineating ablation margins. Electrical conductivity ranged from 0.1892 to 0.5958 S/m and elastic modulus from 6.70 to 138 kPa, effectively encompassing the characteristic properties of diverse lesion tissues. RFA experiments on phantoms mimicking porcine myocardium and chicken breast demonstrated strong agreement with ex vivo results. Ablation of heterogeneous phantoms mimicking atherosclerotic structures revealed significant differences compared to homogeneous models.

Conclusions

A tunable thermochromic phantom formulation was developed, exhibiting a precise color change at 60°C while replicating the electrical and mechanical properties of heterogeneous tissues, enabling direct visualization of ablation boundaries. The phantom offers a robust platform for evaluating catheter-based RFA in clinically relevant complex tissues, supporting the development of personalized and optimized treatment strategies.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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