优化剂量率,以尽量减少输送时间在质子铅笔束剂量驱动的连续扫描

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2025-09-10 DOI:10.1002/mp.18098
Dong Han, Yu Yang, Xiaoying Liang, Hongcheng Liu, Jindong Tong, Sridhar Yaddanapudi, Chunjoo Park, Jun Tan, Keith Furutani, Chris Beltran, Bo Lu
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引用次数: 0

摘要

剂量驱动连续扫描(DDCS)通过减少离散点扫描(DSS)中固有的光束停顿,提高了质子铅笔束传输的效率和精度。然而,目前使用旅行推销员问题(TSP)公式的DDCS优化研究通常依赖于固定光束强度和计算昂贵的插值来生成移动点,限制了效率和方法的鲁棒性。本研究提出了一种断裂点引导(BSG)方法,结合两种加速策略-剂量率跳变和定界-优化光束强度,同时最小化光束传递时间(BDT)。此外,为了平衡计算效率和剂量计算精度,提出了一种有效的σ $\sigma$ -移动点生成方法。方法BSG框架将原混合整数非线性规划(MINLP)问题简化为一系列基于断点剂量率的TSP评价。两种加速策略相结合,降低了计算复杂度。引入σ $\ σ $ -方法,在不影响剂量保真度的情况下有效地产生移动点。在多个临床病例中,对有加速策略和没有加速策略的BSG方法以及σ $\sigma$ -方法的性能进行了评估。结果通过联合优化扫描路径和剂量率,BSG-S-B方法提供了最有效的递送,在前列腺病例中,BDT比DSS减少64%,比Liu的方法减少57%。在所有病例中都一致观察到这些增益。利用加速策略,BSG-S-B显著地将计算时间从小时减少到分钟(例如,前列腺病例从10525.7秒减少到108.5秒,头颈病例从6202.4秒减少到129.8秒)。当与σ $\sigma$ -方法相结合时,它减少了50%以上的移动点数量,同时仍然保证了剂量学质量。结论所提出的框架显著提高了计算效率,使扫描路径优化和剂量率选择在临床DDCS递送中成为可能。σ $\sigma$ -方法在保持剂量计算精度的同时,有效地降低了计算复杂度,在质子治疗方案的临床应用中具有很大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Optimizing dose rate to minimize delivery time in proton pencil beam dose-driven continuous scanning

Optimizing dose rate to minimize delivery time in proton pencil beam dose-driven continuous scanning

Optimizing dose rate to minimize delivery time in proton pencil beam dose-driven continuous scanning

Background

Dose-driven continuous scanning (DDCS) enhances the efficiency and precision of proton pencil beam delivery by reducing beam pauses inherent in discrete spot scanning (DSS). However, current DDCS optimization studies using traveling salesman problem (TSP) formulations often rely on fixed beam intensity and computationally expensive interpolation for move spot generation, limiting efficiency and methodological robustness.

Purpose

This study introduces a Break Spot-Guided (BSG) method, combined with two acceleration strategies—dose rate skipping and bounding—to optimize beam intensity while minimizing beam delivery time (BDT). In addition, a σ $\sigma$ -method is proposed for efficient move spot generation, aiming to balance computational efficiency and dose calculation accuracy.

Methods

The BSG framework simplifies the original mixed-integer nonlinear programming (MINLP) problem by transforming it into a series of TSP evaluations using break-spot dose rates. The two acceleration strategies are integrated to reduce computational complexity. The σ $\sigma$ -method is introduced to efficiently generate move spots without compromising dose fidelity. The performance of the BSG method, with and without the acceleration strategies, and the σ $\sigma$ -method, was evaluated across multiple clinical cases.

Results

By jointly optimizing the scan path and dose rate, the proposed BSG-S-B method offered the most efficient delivery, achieving a 64% reduction in BDT compared to DSS and a 57% reduction compared to Liu's method in the prostate case. These gains were consistently observed across all cases. Utilizing acceleration strategies, BSG-S-B significantly reduced computation time from hours to minutes (e.g., from 10 525.7 to 108.5 s in the prostate case, and from 6202.4 to 129.8 s in the head-and-neck case). When combined with the σ $\sigma$ -method, it reduced the number of move spots by more than 50%, while still ensuring dosimetric quality.

Conclusions

The proposed framework significantly improves computational efficiency, making scan path optimization with dose rate selection feasible for clinical DDCS delivery. The σ $\sigma$ -method effectively reduces computational complexity while maintaining dose calculation accuracy, demonstrating strong potential for clinical adoption in proton therapy treatment planning.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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