Xiao-Ting Yu , Zhen-Hui Fu , Wen-Lin Pan , Yan-Lun Song , Rui-Jie Ma , Hao-Lin Zhang , Xing-He Ke , Shao-Chen Sun , Jun-Li Wang , Lin-Lin Hu
{"title":"铝暴露干扰胚胎早期发育过程中的表观遗传修饰和细胞器功能。","authors":"Xiao-Ting Yu , Zhen-Hui Fu , Wen-Lin Pan , Yan-Lun Song , Rui-Jie Ma , Hao-Lin Zhang , Xing-He Ke , Shao-Chen Sun , Jun-Li Wang , Lin-Lin Hu","doi":"10.1016/j.cbi.2025.111736","DOIUrl":null,"url":null,"abstract":"<div><div>Aluminum is a lightweight and corrosion-resistant metal element that is widely used in industries, construction, food, and pharmaceuticals, and it can adversely affect multiple organ systems including the nervous system, skeletal system, reproductive system, blood system, and immune system. In present study, we investigated the effects of aluminum exposure on mammalian embryo development. Our data demonstrate that aluminum exposure induces mouse early embryo development defects, including those at the zygotes and 2-cell stages, causing a decrease in general transcription activity. We found mitochondrial dysfunction and a significant increase in reactive oxygen species (ROS) levels, thereby triggering oxidative stress, and this oxidative stress subsequently results in DNA damage. Additionally, we observed substantial alterations in histone modification levels, specifically H3K4me2, H3K4me3, H3K27me3, and H4K12ac. These changes in histone modifications were found to be closely associated with the observed DNA damage and mitochondrial dysfunction. We also observed aberrant distribution of lysosomes, endoplasmic reticulum, and Golgi apparatus, indicating that aluminum could disturb protein modification and transport in embryos. In conclusion, our results indicated that aluminum exposure disrupted early embryo development by inducing mitochondria-based oxidative stress, which further caused DNA damage, aberrant histone modifications and organelle functions in mouse embryos.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"421 ","pages":"Article 111736"},"PeriodicalIF":5.4000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aluminum exposure disturbs epigenetic modification and organelle function during early embryo development\",\"authors\":\"Xiao-Ting Yu , Zhen-Hui Fu , Wen-Lin Pan , Yan-Lun Song , Rui-Jie Ma , Hao-Lin Zhang , Xing-He Ke , Shao-Chen Sun , Jun-Li Wang , Lin-Lin Hu\",\"doi\":\"10.1016/j.cbi.2025.111736\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Aluminum is a lightweight and corrosion-resistant metal element that is widely used in industries, construction, food, and pharmaceuticals, and it can adversely affect multiple organ systems including the nervous system, skeletal system, reproductive system, blood system, and immune system. In present study, we investigated the effects of aluminum exposure on mammalian embryo development. Our data demonstrate that aluminum exposure induces mouse early embryo development defects, including those at the zygotes and 2-cell stages, causing a decrease in general transcription activity. We found mitochondrial dysfunction and a significant increase in reactive oxygen species (ROS) levels, thereby triggering oxidative stress, and this oxidative stress subsequently results in DNA damage. Additionally, we observed substantial alterations in histone modification levels, specifically H3K4me2, H3K4me3, H3K27me3, and H4K12ac. These changes in histone modifications were found to be closely associated with the observed DNA damage and mitochondrial dysfunction. We also observed aberrant distribution of lysosomes, endoplasmic reticulum, and Golgi apparatus, indicating that aluminum could disturb protein modification and transport in embryos. In conclusion, our results indicated that aluminum exposure disrupted early embryo development by inducing mitochondria-based oxidative stress, which further caused DNA damage, aberrant histone modifications and organelle functions in mouse embryos.</div></div>\",\"PeriodicalId\":274,\"journal\":{\"name\":\"Chemico-Biological Interactions\",\"volume\":\"421 \",\"pages\":\"Article 111736\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemico-Biological Interactions\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0009279725003667\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemico-Biological Interactions","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0009279725003667","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Aluminum exposure disturbs epigenetic modification and organelle function during early embryo development
Aluminum is a lightweight and corrosion-resistant metal element that is widely used in industries, construction, food, and pharmaceuticals, and it can adversely affect multiple organ systems including the nervous system, skeletal system, reproductive system, blood system, and immune system. In present study, we investigated the effects of aluminum exposure on mammalian embryo development. Our data demonstrate that aluminum exposure induces mouse early embryo development defects, including those at the zygotes and 2-cell stages, causing a decrease in general transcription activity. We found mitochondrial dysfunction and a significant increase in reactive oxygen species (ROS) levels, thereby triggering oxidative stress, and this oxidative stress subsequently results in DNA damage. Additionally, we observed substantial alterations in histone modification levels, specifically H3K4me2, H3K4me3, H3K27me3, and H4K12ac. These changes in histone modifications were found to be closely associated with the observed DNA damage and mitochondrial dysfunction. We also observed aberrant distribution of lysosomes, endoplasmic reticulum, and Golgi apparatus, indicating that aluminum could disturb protein modification and transport in embryos. In conclusion, our results indicated that aluminum exposure disrupted early embryo development by inducing mitochondria-based oxidative stress, which further caused DNA damage, aberrant histone modifications and organelle functions in mouse embryos.
期刊介绍:
Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.