预后营养指数和骨骼肌指数对失代偿期肝硬化预后的联合影响:一项回顾性队列研究。

IF 2.8 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Therapeutic Advances in Chronic Disease Pub Date : 2025-09-03 eCollection Date: 2025-01-01 DOI:10.1177/20406223251369763
Shuangzhe Yao, Binbin Peng, Jia Li, Ziyi Yang, Chao Sun
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引用次数: 0

摘要

背景:肝硬化以慢性炎症为特征,常伴有营养不良。营养指标,如预后营养指数(PNI)和骨骼肌指数(SMI),计算方法是通过CT扫描在第三腰椎水平量化的肌肉面积除以患者身高的平方,以米为单位(cm2/m2),与炎症性疾病的结局相关。目的:我们旨在评估PNI单独和联合SMI诊断肝硬化营养不良的疗效,并探讨其预后意义。设计:对262例住院肝硬化患者(2018-2023)进行单中心回顾性队列研究。营养不良分别采用PNI、PNI- smi和全球营养不良领导倡议(GLIM)标准进行评估。方法:营养状况由PNI定义(结果:各种标准确定的营养不良患病率差异很大:PNI标准为26.72%,PNI- smi标准为56.11%,GLIM标准为51.14%)。被分类为营养不良的患者表现出较差的临床参数和较高的1年死亡率。PNI-SMI联合诊断营养不良表现良好,灵敏度为75.51%,特异度为80%,曲线下面积为0.774。多因素Cox分析显示,所有三个营养不良标准与1年全因死亡率独立相关,风险比分别为2.56、4.20和7.20。结论:PNI,特别是与SMI结合时,为失代偿期肝硬化的营养和预后评估提供了一种简化但中等准确的工具。这种联合方法可以作为临床上GLIM标准的实际补充,通过有针对性的营养干预可能改善结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Joint effects of prognostic nutritional index and skeletal muscle index on prognosis of decompensated cirrhosis: a retrospective cohort study.

Joint effects of prognostic nutritional index and skeletal muscle index on prognosis of decompensated cirrhosis: a retrospective cohort study.

Joint effects of prognostic nutritional index and skeletal muscle index on prognosis of decompensated cirrhosis: a retrospective cohort study.

Joint effects of prognostic nutritional index and skeletal muscle index on prognosis of decompensated cirrhosis: a retrospective cohort study.

Background: Liver cirrhosis, characterized by chronic inflammation, is frequently complicated by malnutrition. Nutritional indices, such as the prognostic nutritional index (PNI) and the skeletal muscle index (SMI), calculated as the muscle area quantified via CT scans at the third lumbar vertebra level divided by the square of the patient's height in meters (cm2/m2), are associated with outcomes in inflammatory diseases.

Objectives: We aimed to evaluate the diagnostic efficacy of the PNI both independently and in combination with the SMI for identifying malnutrition in cirrhosis and to explore their prognostic implications.

Design: A single-center retrospective cohort study of 262 hospitalized cirrhotic patients (2018-2023). Malnutrition was assessed using PNI, PNI-SMI, and Global Leadership Initiative on Malnutrition (GLIM) criteria, respectively.

Methods: Nutritional status was defined by PNI (<28.85), PNI-SMI (either reduced PNI or SMI), and GLIM criteria. SMI was quantified via third lumbar vertebra CT scans. Diagnostic performance was evaluated using sensitivity, specificity, and area under the curve (AUC). Cox regression and Kaplan-Meier analyses assessed associations with 1-year mortality.

Results: The prevalence of malnutrition, as determined by various criteria, was considerably heterogeneous: 26.72% by the PNI, 56.11% by the PNI-SMI, and 51.14% by the GLIM criteria. Patients classified as malnourished demonstrated inferior clinical parameters and a higher 1-year mortality rate. The PNI-SMI combination exhibited favorable diagnostic performance in detecting malnutrition, with a sensitivity of 75.51%, specificity of 80%, along with an area under the curve of 0.774. Multivariate Cox analysis indicated that all three malnutrition criteria were independently associated with 1-year all-cause mortality, with hazard ratios of 2.56, 4.20, and 7.20, respectively.

Conclusion: The PNI, particularly when integrated with the SMI, offers a streamlined yet moderately accurate tool for nutritional and prognostic assessment in decompensated cirrhosis. This combined approach may serve as a practical supplement to GLIM criteria in select clinical contexts, potentially improving outcomes through targeted nutritional interventions.

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来源期刊
Therapeutic Advances in Chronic Disease
Therapeutic Advances in Chronic Disease Medicine-Medicine (miscellaneous)
CiteScore
6.20
自引率
0.00%
发文量
108
审稿时长
12 weeks
期刊介绍: Therapeutic Advances in Chronic Disease publishes the highest quality peer-reviewed research, reviews and scholarly comment in the drug treatment of all chronic diseases. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers involved in the medical treatment of chronic disease, providing a forum in print and online for publishing the highest quality articles in this area.
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