Alex Stubbing-Moore, Hussein Uraiby, Vincent Lam, Samira Anwar-Bhatti
{"title":"模拟Tolosa-Hunt综合征的隐匿性皮肤鳞状细胞癌的神经周围浸润。","authors":"Alex Stubbing-Moore, Hussein Uraiby, Vincent Lam, Samira Anwar-Bhatti","doi":"10.1080/01658107.2024.2367054","DOIUrl":null,"url":null,"abstract":"<p><p>We report a case of painful left abducens nerve palsy that progressed to a left cavernous sinus syndrome (CSS). The initial differential diagnosis was Tolosa-Hunt syndrome (THS), but the clinical course was atypical. Subsequently, perineural invasion (PNI) was demonstrated, after biopsy of a previously occult undiagnosed new cutaneous squamous cell carcinoma (SCC) of the forehead. This case emphasizes the challenges of diagnosing painful ophthalmoplegia when there is an absence of positive neuroimaging or typical findings. The take home message is that a detailed medical history and high index of suspicion are necessary in suspected THS.</p>","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 1","pages":"87-94"},"PeriodicalIF":0.8000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409859/pdf/","citationCount":"0","resultStr":"{\"title\":\"Perineural Invasion of Occult Cutaneous Squamous Cell Carcinoma Mimicking Tolosa-Hunt Syndrome.\",\"authors\":\"Alex Stubbing-Moore, Hussein Uraiby, Vincent Lam, Samira Anwar-Bhatti\",\"doi\":\"10.1080/01658107.2024.2367054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We report a case of painful left abducens nerve palsy that progressed to a left cavernous sinus syndrome (CSS). The initial differential diagnosis was Tolosa-Hunt syndrome (THS), but the clinical course was atypical. Subsequently, perineural invasion (PNI) was demonstrated, after biopsy of a previously occult undiagnosed new cutaneous squamous cell carcinoma (SCC) of the forehead. This case emphasizes the challenges of diagnosing painful ophthalmoplegia when there is an absence of positive neuroimaging or typical findings. The take home message is that a detailed medical history and high index of suspicion are necessary in suspected THS.</p>\",\"PeriodicalId\":19257,\"journal\":{\"name\":\"Neuro-Ophthalmology\",\"volume\":\"49 1\",\"pages\":\"87-94\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409859/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuro-Ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/01658107.2024.2367054\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuro-Ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/01658107.2024.2367054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
We report a case of painful left abducens nerve palsy that progressed to a left cavernous sinus syndrome (CSS). The initial differential diagnosis was Tolosa-Hunt syndrome (THS), but the clinical course was atypical. Subsequently, perineural invasion (PNI) was demonstrated, after biopsy of a previously occult undiagnosed new cutaneous squamous cell carcinoma (SCC) of the forehead. This case emphasizes the challenges of diagnosing painful ophthalmoplegia when there is an absence of positive neuroimaging or typical findings. The take home message is that a detailed medical history and high index of suspicion are necessary in suspected THS.
期刊介绍:
Neuro-Ophthalmology publishes original papers on diagnostic methods in neuro-ophthalmology such as perimetry, neuro-imaging and electro-physiology; on the visual system such as the retina, ocular motor system and the pupil; on neuro-ophthalmic aspects of the orbit; and on related fields such as migraine and ocular manifestations of neurological diseases.