涎腺未分化癌的特征:与淋巴上皮癌比较的临床病理和免疫组织化学分析。

IF 3 Q3 PATHOLOGY
Sangjoon Choi, Gyuheon Choi, Hee Jin Lee, Joon Seon Song, Yoon Se Lee, Seung-Ho Choi, Kyung-Ja Cho
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引用次数: 0

摘要

背景:本研究旨在将一个低分化唾液腺癌亚群重新分类,该亚群不符合当前世界卫生组织(WHO)分类的任何实体,因为它们缺乏特定的组织学分化或免疫表型,因此不符合未分化癌(UDC)的分类。方法:回顾性分析2002-2020年峨山医学中心收治的不符合WHO现有分类标准、诊断为低分化癌、高级别癌或UDC的唾液腺癌病例。对p40、神经内分泌标志物、雄激素受体(AR)、总囊性疾病液蛋白15 (GCDFP-15)和eb病毒(EBV)原位杂交(ISH)进行免疫组化(IHC)染色。临床数据从电子病历中收集。结果:6例唾液腺癌不与任何特定实体一致,缺乏明显的分化。6例中有2例显示淋巴上皮癌(LEC)样形态,但p40和EBV ISH免疫反应性阴性或可忽略不计,与唾液腺LEC区分开来。2例AR阳性,提示可能与涎腺管癌(SDC)重叠,但缺乏典型的SDC形态和GCDFP-15表达。无神经内分泌标志物表达。结论:本研究建议基于其不确定的分化和免疫结构特征,将这些低分化或高级别唾液腺癌重新分类为UDC。这可能会导致更清晰的诊断分类,并提高我们对这些高级别肿瘤的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of undifferentiated carcinoma of the salivary gland: clinicopathological and immunohistochemical analyses in comparison with lymphoepithelial carcinoma.

Background: This study aimed to reclassify a subset of poorly differentiated salivary gland carcinoma that do not conform to any entities of the current World Health Organization (WHO) classification into the category of undifferentiated carcinoma (UDC) because they lack specific histologic differentiation or immunophenotype.

Methods: Cases of salivary gland carcinomas from Asan Medical Center (2002-2020) that did not fit any existing WHO classification criteria and were diagnosed as poorly differentiated carcinoma, high-grade carcinoma, or UDC, were retrospectively reviewed. Immunohistochemical (IHC) staining for p40, neuroendocrine markers, androgen receptor (AR), and gross cystic disease fluid protein 15 (GCDFP-15) and Epstein-Barr virus (EBV) in situ hybridization (ISH) were performed. Clinical data were collected from the electronic medical records.

Results: Six salivary gland carcinomas did not align with any specific entities and lacked distinct differentiation. Two of six cases displayed lymphoepithelial carcinoma (LEC)-like morphology but were negative or showed negligible immunoreactivity for p40 and EBV ISH, distinguishing them from LEC of the salivary gland. Two cases showed strong AR positivity, suggesting a potential overlap with salivary duct carcinoma (SDC) but lacked classic SDC morphologies and GCDFP-15 expression. No cases expressed neuroendocrine markers.

Conclusions: This study proposes reclassifying these poorly differentiated or high-grade salivary gland carcinomas as UDC based on their indeterminate differentiation and IHC profiles. This may lead to a clearer diagnostic category and enhance our understanding of these high-grade tumors.

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来源期刊
CiteScore
5.00
自引率
4.20%
发文量
45
审稿时长
14 weeks
期刊介绍: The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.
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