慢性阻塞性肺病急性加重期δ中性粒细胞指数和其他血液学参数的回顾性研究。

IF 2.1 4区 医学 Q3 RESPIRATORY SYSTEM
Canadian respiratory journal Pub Date : 2025-08-28 eCollection Date: 2025-01-01 DOI:10.1155/carj/3647362
Burcu Akkok, Evrim Gulderen Kuscu, Hatice Sahin
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引用次数: 0

摘要

背景:慢性阻塞性肺疾病(COPD)是世界范围内发病率和死亡率不断上升的原因,急性加重是COPD患者的主要健康问题。在这项研究中,我们旨在探讨δ中性粒细胞指数(DNI)与其他血液学参数在管理和指导COPD急性加重患者中的作用。方法:回顾性研究2021年5月至2023年12月期间,在肺科门诊、重症监护病房和麻醉与复苏病房内接受急性加重治疗的COPD患者。回顾性评估每日就诊记录。根据病原菌分为细菌性和非细菌性两组。结果:心力衰竭患者的中位DNI值明显较高(p: 0.026),而没有单独记录的其他合并症患者的中位DNI值明显较低(p: 0.026)。白细胞(WBC)、中性粒细胞、未成熟粒细胞值(绝对值和百分比)、血小板、血小板-淋巴细胞比值(PLR)、中性粒细胞-淋巴细胞比值(NLR)、c反应蛋白(CRP)、降钙素原、血培养阳性、全身炎症反应综合征(SIRS)阳性标准和脓毒症在细菌急性加重患者中显著升高。同一组的住院时间也明显更长(p: 0.006)。中位DNI值与早期死亡率(28天内)、30天内再入院率和6个月内无统计学意义相关。结论:在本研究中,我们已经证明血清降钙素原水平、WBC、NLR和PLR测量可用于区分细菌性和非细菌性COPD加重。DNI在30天和6个月的早期死亡率、机械通气需求或再入院方面没有预后预测价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Delta Neutrophil Index and Other Hematologic Parameters in Acute Exacerbations of COPD: A Retrospective Study.

Delta Neutrophil Index and Other Hematologic Parameters in Acute Exacerbations of COPD: A Retrospective Study.

Background: Chronic obstructive pulmonary disease (COPD) is an increasing cause of morbidity and mortality worldwide, and acute exacerbations are the major health issues in COPD patients. In this study, we aimed to investigate the role of the delta neutrophil index (DNI) with other hematologic parameters in managing and guiding COPD patients admitted with acute exacerbations. Methods: In this retrospective study, COPD patients treated internally in pulmonology clinic, intensive care unit, and anesthesiology and reanimation unit with acute exacerbation between May 2021 and December 2023 were investigated. Records from daily visits were evaluated retrospectively. Patients were divided into two groups according to the causative organism: bacterial or nonbacterial. Results: Patients with cardiac failure were found to have significantly higher median DNI values (p : 0.026), whereas patients with other comorbidities that were not individually recorded have substantially lower median DNI values (p : 0.026). White blood cell (WBC), neutrophil, immature granulocyte values (both absolute value and percent), thrombocyte, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), procalcitonin, positive blood culture, positive systemic inflammatory response syndrome (SIRS) criteria, and sepsis were significantly higher in patients with bacterial acute exacerbation. Hospitalization duration was also significantly longer in the same group (p :  0.006). No statistically significant correlation was found between median DNI values and early mortality rate (within 28 days), readmission within 30 days and 6 months. Conclusion: In this study, we have shown that the serum procalcitonin level, WBC, NLR, and PLR measurement can be used to distinguish bacterial and nonbacterial COPD exacerbations. The DNI revealed no prognostic predictive value regarding early mortality, mechanic ventilation need, or readmission in 30 days and 6 months.

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来源期刊
Canadian respiratory journal
Canadian respiratory journal 医学-呼吸系统
CiteScore
4.20
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.
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