Zhiping Liu, Lijie Che, Jie Pang, Xiyan Tang, Chunfang Gan, Jianguo Cui, Yanmin Huang
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Design, Synthesis, and Antiproliferative Activity of New Selenocyanate-Containing Selenophenol Amide Derivatives
Twelve novel amide-linked selenophenol selenocyanates were synthesized by integrating selenocyanates into selenophenol rings via amide bonds with diversified alkyl chain lengths. Their structures were confirmed by 1H/13C NMR and HR-MS. The antiproliferation activities of these compounds was assessed using the MTT assay against multiple cancer cell lines. Notably, compound 6h exhibited potent inhibitory effects against SKOV-3 cells (IC50 = 1.96 μM), while compound 6l demonstrated significant activity against MCF-7 (IC50 = 7.29 μM) and HepG-2 cells (IC50 = 6.71 μM). These results suggest that these selenophenol selenocyanate derivatives represent a promising class of small-molecule selenium-based therapeutics, warranting further investigations for potential medicinal applications.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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