Nima Yassini, Eva Goljat, Camilla Panetti, Matthias Rath, Nicole Joller
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CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation
Memory T cells, a sizable compartment of the mature immune system, enable enhanced responses upon re-infection with the same pathogen. We have recently shown that virus-experienced innate acting T (TIA) cells can modulate infectious or autoimmune diseases through TCR-independent IFN-γ production. However, how these cells arise remains unclear. Here, we show that CD4 TIA cells are present in various disease settings hinting towards a disease-agnostic nature. TCR stimulation and CD28 co-stimulation are sufficient to induce naïve murine and human CD4 T cells to become capable of cytokine-mediated, TCR-independent IFN-γ responses. In true TIA fashion, adoptive transfer of in vitro-induced TIA cells in mice yielded a TCR-independent IFN-γ response during the innate phase of a Legionella pneumophila infection. Our data thus shows that CD4 TIA cells are more ubiquitous than anticipated and could therefore be involved in more settings than expected.
期刊介绍:
The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.