CD4 T细胞通过经典T细胞激活获得先天能力

IF 3.7 3区 医学 Q2 IMMUNOLOGY
Nima Yassini, Eva Goljat, Camilla Panetti, Matthias Rath, Nicole Joller
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引用次数: 0

摘要

记忆T细胞是成熟免疫系统的一个相当大的隔室,能够增强对同一病原体再次感染的反应。我们最近表明,病毒经历的先天作用T (TIA)细胞可以通过tcr独立的IFN-γ产生来调节感染性或自身免疫性疾病。然而,这些细胞是如何产生的仍不清楚。在这里,我们表明CD4 TIA细胞存在于各种疾病环境中,暗示疾病不可知的性质。TCR刺激和CD28共同刺激足以诱导naïve小鼠和人类CD4 T细胞能够产生细胞因子介导的、不依赖于TCR的IFN-γ反应。在真正的TIA方式中,在嗜肺军团菌感染的先天期,小鼠体内体外诱导的TIA细胞过继转移产生了tcr独立的IFN-γ反应。因此,我们的数据表明CD4 TIA细胞比预期的更普遍,因此可能涉及比预期更多的环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation

CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation

Memory T cells, a sizable compartment of the mature immune system, enable enhanced responses upon re-infection with the same pathogen. We have recently shown that virus-experienced innate acting T (TIA) cells can modulate infectious or autoimmune diseases through TCR-independent IFN-γ production. However, how these cells arise remains unclear. Here, we show that CD4 TIA cells are present in various disease settings hinting towards a disease-agnostic nature. TCR stimulation and CD28 co-stimulation are sufficient to induce naïve murine and human CD4 T cells to become capable of cytokine-mediated, TCR-independent IFN-γ responses. In true TIA fashion, adoptive transfer of in vitro-induced TIA cells in mice yielded a TCR-independent IFN-γ response during the innate phase of a Legionella pneumophila infection. Our data thus shows that CD4 TIA cells are more ubiquitous than anticipated and could therefore be involved in more settings than expected.

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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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