整合支持草甘膦可能的发育性神经毒性(DNT)的不同证据流

IF 2.9 3区 医学 Q2 TOXICOLOGY
A.F. Hernández
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引用次数: 0

摘要

草甘膦是草甘膦基除草剂(GBHs)的活性成分,被广泛用于杂草控制,最近人们对其潜在的发育神经毒性(DNT)感到担忧。欧盟的监管评估已经确定了草甘膦DNT研究的关键数据缺口。本报告综合了来自流行病学,体内和新方法方法(NAMs)的证据来评估其神经发育作用。流行病学研究得出了不一致的结果。一些报道称产前草甘膦暴露与自闭症谱系障碍(ASD)、注意力缺陷多动障碍(ADHD)和发育迟缓有关,而另一些则没有发现显著联系。这些不一致可归因于暴露评估和研究设计的差异。动物研究提供了更一致的证据,支持对神经发育的影响。啮齿动物模型表明,草甘膦暴露会破坏神经递质系统,诱导氧化应激,改变内分泌信号,促进神经炎症,导致认知障碍,焦虑样行为和社交障碍。然而,这些影响主要是与GBHs一起观察到的,而不是单独使用草甘膦。监管指南研究仍然有限,只有一项关于草甘膦三甲基的DNT研究报告了积极的影响,尽管这种形式并不代表草甘膦的毒理学概况。斑马鱼研究进一步证实了草甘膦潜在的神经毒性。体外研究表明,草甘膦诱导细胞凋亡,破坏神经元分化,激活神经胶质细胞,而计算机模拟预测与神经递质受体和内分泌通路的相互作用。值得注意的是,GBHs似乎比单独的草甘膦更具神经毒性,可能是由于表面活性剂成分增强毒性。证据加权方法表明,虽然GBHs可能会造成神经发育风险,但草甘膦的DNT责任尚未确定。通过进一步研究解决已确定的数据差距对于完善其神经毒理学概况至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
S07-01 Integration of different streams of evidence supporting possible developmental neurotoxicity (DNT) of glyphosate
Glyphosate, the active ingredient in glyphosate-based herbicides (GBHs), is extensively used for weed control, with recent concerns emerging over its potential developmental neurotoxicity (DNT). Regulatory assessments in the EU have identified a critical data gap regarding DNT studies on glyphosate acid. This presentation synthesises evidence from epidemiological, in vivo, and new approach methodologies (NAMs) to assess its neurodevelopmental effects. Epidemiological studies yielded inconsistent findings. Some reported associations between prenatal glyphosate exposure and autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and developmental delays, while others find no significant links. These inconsistencies can be attributed to variations in exposure assessment and study design. Animal studies provide more consistent evidence supporting neurodevelopmental effects. Rodent models indicate that glyphosate exposure disrupts neurotransmitter systems, induces oxidative stress, alters endocrine signalling, and promotes neuroinflammation, leading to cognitive impairments, anxiety-like behaviours, and deficits in social interaction. However, these effects are primarily observed with GBHs rather than glyphosate alone. Regulatory guideline studies remain limited, with a single DNT study on glyphosate trimesium reporting positive effects, though this form is not representative of glyphosate acid's toxicological profile. Zebrafish studies further corroborate glyphosate's neurotoxic potential. In vitro research shows that glyphosate induces apoptosis, disrupts neuronal differentiation, and activates glial cells, while in silico modelling predicts interactions with neurotransmitter receptors and endocrine pathways. Remarkably, GBHs appear more neurotoxic than glyphosate alone, likely due to surfactant components enhancing toxicity. A weight-of-evidence approach suggests that while GBHs may pose neurodevelopmental risks, no definitive DNT liabilities for glyphosate acid have been established. Addressing the identified data gap through further research is essential to refine its neurotoxicological profile.
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来源期刊
Toxicology letters
Toxicology letters 医学-毒理学
CiteScore
7.10
自引率
2.90%
发文量
897
审稿时长
33 days
期刊介绍: An international journal for the rapid publication of novel reports on a range of aspects of toxicology, especially mechanisms of toxicity.
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