将NAM数据集成到自下而上的PBK建模方法中

IF 2.9 3区医学 Q2 TOXICOLOGY

Toxicology letters Pub Date : 2025-09-01 DOI:10.1016/j.toxlet.2025.07.090

M. Spänig

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引用次数: 0

摘要

下一代风险评估旨在减少并最终取代动物试验，同时确保对该方法的信心。来自ADME4NGRA和PARC等正在进行的项目的最新结果将被分享，以说明如何在硅和体外基于nama的数据可以在PBK建模中实现。这种整合对于制定更可靠和合乎道德的化学品安全评估框架至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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S14-04 Integrate NAM data into bottom-up PBK modelling approaches

Next generation risk assessment aims to reduce and ultimately replace animal testing while ensuring confidence in the approach. Recent results from ongoing projects such as ADME4NGRA and PARC will be shared to illustrate how in silico and in vitro NAM-based data can be implemented in PBK modelling. This integration is essential for the development of more reliable and ethical frameworks for chemical safety assessment.

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