超越传统的危险因素：确定术前血清铁蛋白作为结肠手术后吻合口漏的新预测因子

IF 2.4 4区医学 Q3 ONCOLOGY

Surgical Oncology-Oxford Pub Date : 2025-09-02 DOI:10.1016/j.suronc.2025.102283

Mohamed Hassin Mohamed Chairi , Patricia Josefina Madroñal Escribano , Alicia Ron García , María José Alonso Sebastián , Patricia Vílchez Fernández , Mónica Mogollón González , Per Anderson , María Elena Rodríguez-Cabezas , María del Carmen Olvera Porcel , José Tomás Torres Alcalá , Francisco José Huertas Peña

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引用次数: 0

摘要

目的探讨结肠切除术后吻合口漏（AL）的预测危险因素。方法对2018年1月至2023年12月行结肠切除结肠/结直肠吻合术患者进行观察性和回顾性队列研究。对人口统计、患者、手术和结局数据进行分析。通过单因素和多因素分析确定危险因素。结果本研究共纳入639例行结肠吻合术的患者。其中62例（9.7%）发生AL。单因素分析发现，年龄、男性、术前血清铁蛋白水平51.75 ng/mL、微创手术入路、扩大切除、术前c -反应蛋白水平10mg /L是AL的相关因素。多因素分析显示，术前血清铁蛋白水平（OR 5.55, p = 0.001）、术前c -反应蛋白水平（OR 54.97, p = 0.001）、p < 0.001)是AL的独立且显著的预测因子。结论我们的研究发现术前c反应蛋白是AL的预测因子，与文献报道的结果一致，并强调术前血清铁蛋白是结肠吻合术后AL的一个新的预测因子。

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Beyond traditional risk factors: The identification of preoperative serum ferritin as a novel predictor of anastomotic leakage after colonic surgery

Aim

To identify predictive risk factors associated with anastomotic leakage (AL) following colon resection surgery.

Method

Observational and retrospective cohort study of patients undergoing colon resection with colonic/colorectal anastomosis from January 2018 to December 2023. Demographic, patient, surgery, and outcome data were analysed. Risk factors were identified with both univariate and multivariate analysis.

Results

A total of 639 patients who underwent colon resection with anastomosis were included in this study. Among them, 62 patients (9.7 %) developed AL. Univariate analysis identified age, male sex, preoperative serum ferritin levels >51.75 ng/mL, minimally invasive surgical approach, extended resection and preoperative C-reactive protein levels >10 mg/L as factors associated with AL. Multivariate analysis revealed that preoperative serum ferritin (OR 5.55, p = 0.001) and preoperative C-reactive protein levels (OR 54.97, p < 0.001) were independent and significant predictors of AL.

Conclusion

Our study has identified preoperative C-reactive protein as a predictor of AL, consistent with findings reported in the literature, and highlights preoperative serum ferritin as a novel predictor of AL following colonic anastomosis.

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来源期刊

Surgical Oncology-Oxford 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

169

审稿时长

38 days

期刊介绍： Surgical Oncology is a peer reviewed journal publishing review articles that contribute to the advancement of knowledge in surgical oncology and related fields of interest. Articles represent a spectrum of current technology in oncology research as well as those concerning clinical trials, surgical technique, methods of investigation and patient evaluation. Surgical Oncology publishes comprehensive Reviews that examine individual topics in considerable detail, in addition to editorials and commentaries which focus on selected papers. The journal also publishes special issues which explore topics of interest to surgical oncologists in great detail - outlining recent advancements and providing readers with the most up to date information.