人类缓释纳曲酮的芬太尼阻断效应：三例报告。

Q3 Medicine

Journal of opioid management Pub Date : 2025-07-01 DOI:10.5055/jom.0949

Colin Brewer

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引用次数: 0

摘要

尽管微激动剂芬太尼对美国阿片类药物过量流行有贡献，但没有人体研究专门探讨阿片类拮抗剂纳曲酮（NTX）缓释制剂阻断芬太尼危及生命的微激动剂介导的呼吸抑制的能力。本文介绍了三例阿片类药物滥用患者植入缓释NTX （ER-NTX）的临床必要阿片类药物挑战的病史。它还回顾了稀少的文献，并首次证明ER-NTX制剂的拮抗剂血液水平可以完全阻断静脉注射芬太尼至少1000微克的致死性微激动剂作用。

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Fentanyl-blocking effects of extended-release naltrexone in humans: Three case reports.

Despite the contribution of the µ-agonist fentanyl to the United States's opiate overdose epidemic, no human studies specifically address the ability of extended-release preparations of the opiate antagonist naltrexone (NTX) to block fentanyl's life-threatening µ-agonist-mediated respiratory depression. This paper presents three case histories of clinically necessary opiate challenges in opiate-abusing patients implanted with extended-release NTX (ER-NTX). It also reviews the sparse literature and is the first evidence that antagonist blood levels from ER-NTX preparations can completely block the lethal µ-agonist effects of at least 1,000 mcg of intravenous fentanyl.

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来源期刊

Journal of opioid management Medicine-Anesthesiology and Pain Medicine

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： The Journal of Opioid Management deals with all aspects of opioids. From basic science, pre-clinical, clinical, abuse, compliance and addiction medicine, the journal provides and unbiased forum for researchers and clinicians to explore and manage the complexities of opioid prescription.