{"title":"缓冲脑老化：教育减轻帕金森病的语言障碍。","authors":"Minchul Kim, Kwangsun Yoo","doi":"10.3389/fncel.2025.1606451","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cognitive reserve (CR) refers to the discrepancy between brain pathology and observed cognitive decline. While education is a key indicator of CR, its role as a potential moderator in the relationships between brain morphology and cognitive impairments in Parkinson's disease (PD) remains unclear. This study examined whether education affects the relationship between brain age and cognitive impairments in patients with PD.</p><p><strong>Methods: </strong>Data from 58 patients with PD were analyzed using a secondary dataset from the OpenNeuro database. Participants aged ≥55 years were on stable medications and underwent standardized neuropsychological assessments. Brain age predictions were generated from T1-weighted magnetic resonance imaging (MRI) using the brainageR package, and the brain age difference (BAD) was calculated after correction for regression dilution. The moderation effect of education on the relationship between BAD and cognition was assessed using Hayes' PROCESS macro. The primary outcome was cognitive performance across six domains: attention, executive function, language, learning and memory, visuospatial ability, and global cognition.</p><p><strong>Results: </strong>Among the six domains, a significant moderation effect of education was found only for language ability (β = 0.01, <i>p</i> = 0.013, <i>R</i> <sup>2</sup> = 0.20). The relationship between BAD and language was steeper at lower education levels. No statistically significant moderation was found in the remaining five domains.</p><p><strong>Conclusion: </strong>Having more years of education is associated with buffering the effects of accelerated brain aging on language ability in PD.</p>","PeriodicalId":12432,"journal":{"name":"Frontiers in Cellular Neuroscience","volume":"19 ","pages":"1606451"},"PeriodicalIF":4.0000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405238/pdf/","citationCount":"0","resultStr":"{\"title\":\"Buffering brain aging: education moderates language impairment in Parkinson's disease.\",\"authors\":\"Minchul Kim, Kwangsun Yoo\",\"doi\":\"10.3389/fncel.2025.1606451\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cognitive reserve (CR) refers to the discrepancy between brain pathology and observed cognitive decline. While education is a key indicator of CR, its role as a potential moderator in the relationships between brain morphology and cognitive impairments in Parkinson's disease (PD) remains unclear. This study examined whether education affects the relationship between brain age and cognitive impairments in patients with PD.</p><p><strong>Methods: </strong>Data from 58 patients with PD were analyzed using a secondary dataset from the OpenNeuro database. Participants aged ≥55 years were on stable medications and underwent standardized neuropsychological assessments. Brain age predictions were generated from T1-weighted magnetic resonance imaging (MRI) using the brainageR package, and the brain age difference (BAD) was calculated after correction for regression dilution. The moderation effect of education on the relationship between BAD and cognition was assessed using Hayes' PROCESS macro. The primary outcome was cognitive performance across six domains: attention, executive function, language, learning and memory, visuospatial ability, and global cognition.</p><p><strong>Results: </strong>Among the six domains, a significant moderation effect of education was found only for language ability (β = 0.01, <i>p</i> = 0.013, <i>R</i> <sup>2</sup> = 0.20). The relationship between BAD and language was steeper at lower education levels. No statistically significant moderation was found in the remaining five domains.</p><p><strong>Conclusion: </strong>Having more years of education is associated with buffering the effects of accelerated brain aging on language ability in PD.</p>\",\"PeriodicalId\":12432,\"journal\":{\"name\":\"Frontiers in Cellular Neuroscience\",\"volume\":\"19 \",\"pages\":\"1606451\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405238/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Cellular Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fncel.2025.1606451\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cellular Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fncel.2025.1606451","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Buffering brain aging: education moderates language impairment in Parkinson's disease.
Background: Cognitive reserve (CR) refers to the discrepancy between brain pathology and observed cognitive decline. While education is a key indicator of CR, its role as a potential moderator in the relationships between brain morphology and cognitive impairments in Parkinson's disease (PD) remains unclear. This study examined whether education affects the relationship between brain age and cognitive impairments in patients with PD.
Methods: Data from 58 patients with PD were analyzed using a secondary dataset from the OpenNeuro database. Participants aged ≥55 years were on stable medications and underwent standardized neuropsychological assessments. Brain age predictions were generated from T1-weighted magnetic resonance imaging (MRI) using the brainageR package, and the brain age difference (BAD) was calculated after correction for regression dilution. The moderation effect of education on the relationship between BAD and cognition was assessed using Hayes' PROCESS macro. The primary outcome was cognitive performance across six domains: attention, executive function, language, learning and memory, visuospatial ability, and global cognition.
Results: Among the six domains, a significant moderation effect of education was found only for language ability (β = 0.01, p = 0.013, R2 = 0.20). The relationship between BAD and language was steeper at lower education levels. No statistically significant moderation was found in the remaining five domains.
Conclusion: Having more years of education is associated with buffering the effects of accelerated brain aging on language ability in PD.
期刊介绍：
Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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