Vitaris Kodogo, Karen Sliwa, Alice M Jackson, Hasan Al-Farhan, Sorel Goland, Jasper Tromp, Peter van der Meer, Kamilu Karaye, Alexandre Mebazaa, Johann Bauersachs, Liam Bell, Julian Hoevelmann, Charle Viljoen
{"title":"围产期心肌病蛋白质生物标志物的种族差异：EORP队列的蛋白质组学研究。","authors":"Vitaris Kodogo, Karen Sliwa, Alice M Jackson, Hasan Al-Farhan, Sorel Goland, Jasper Tromp, Peter van der Meer, Kamilu Karaye, Alexandre Mebazaa, Johann Bauersachs, Liam Bell, Julian Hoevelmann, Charle Viljoen","doi":"10.1002/ehf2.15419","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>The diagnosis of peripartum cardiomyopathy (PPCM) is often delayed due to the absence of disease-specific biomarkers. Recently, serum proteins-QSOX1, adiponectin (ADIPOQ) and ITIH3-have shown potential for improving diagnostic accuracy, especially when used with NT-proBNP. However, the influence of ethnicity on their expression remains unclear. We aimed to assess whether serum biomarker profiles differ among ethnic groups in a multinational PPCM cohort.</p><p><strong>Methods and results: </strong>Eighty-two PPCM patients from seven countries in the EURObservational Research Programme (EORP) provided demographic data and serum samples. Ethnicity was self-reported. Proteomic profiling at diagnosis was performed using DIA-based label-free LC-MS, and data were analysed with Spectronaut v15. Ethnic variation was evaluated through principal component analysis (PCA). Participants had a mean age of 30.5 ± 6.7 years; 75% had no hypertension during pregnancy. Median LVEF was 35% (IQR 27.0-41.1), with no ethnic differences. Middle Eastern women showed more severe LV dilatation. PCA revealed no significant clustering by ethnicity; PC1 and PC2 explained 15.2% and 12.0% of variance, respectively.</p><p><strong>Conclusions: </strong>QSOX1, ADIPOQ and ITIH3 exhibited consistent expressions across ethnic groups, supporting their use as universal PPCM biomarkers.</p>","PeriodicalId":11864,"journal":{"name":"ESC Heart Failure","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ethnic differences in protein biomarkers of peripartum cardiomyopathy: a proteomic study on the EORP cohort.\",\"authors\":\"Vitaris Kodogo, Karen Sliwa, Alice M Jackson, Hasan Al-Farhan, Sorel Goland, Jasper Tromp, Peter van der Meer, Kamilu Karaye, Alexandre Mebazaa, Johann Bauersachs, Liam Bell, Julian Hoevelmann, Charle Viljoen\",\"doi\":\"10.1002/ehf2.15419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>The diagnosis of peripartum cardiomyopathy (PPCM) is often delayed due to the absence of disease-specific biomarkers. Recently, serum proteins-QSOX1, adiponectin (ADIPOQ) and ITIH3-have shown potential for improving diagnostic accuracy, especially when used with NT-proBNP. However, the influence of ethnicity on their expression remains unclear. We aimed to assess whether serum biomarker profiles differ among ethnic groups in a multinational PPCM cohort.</p><p><strong>Methods and results: </strong>Eighty-two PPCM patients from seven countries in the EURObservational Research Programme (EORP) provided demographic data and serum samples. Ethnicity was self-reported. Proteomic profiling at diagnosis was performed using DIA-based label-free LC-MS, and data were analysed with Spectronaut v15. Ethnic variation was evaluated through principal component analysis (PCA). Participants had a mean age of 30.5 ± 6.7 years; 75% had no hypertension during pregnancy. Median LVEF was 35% (IQR 27.0-41.1), with no ethnic differences. Middle Eastern women showed more severe LV dilatation. PCA revealed no significant clustering by ethnicity; PC1 and PC2 explained 15.2% and 12.0% of variance, respectively.</p><p><strong>Conclusions: </strong>QSOX1, ADIPOQ and ITIH3 exhibited consistent expressions across ethnic groups, supporting their use as universal PPCM biomarkers.</p>\",\"PeriodicalId\":11864,\"journal\":{\"name\":\"ESC Heart Failure\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ESC Heart Failure\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ehf2.15419\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ESC Heart Failure","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ehf2.15419","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Ethnic differences in protein biomarkers of peripartum cardiomyopathy: a proteomic study on the EORP cohort.
Aims: The diagnosis of peripartum cardiomyopathy (PPCM) is often delayed due to the absence of disease-specific biomarkers. Recently, serum proteins-QSOX1, adiponectin (ADIPOQ) and ITIH3-have shown potential for improving diagnostic accuracy, especially when used with NT-proBNP. However, the influence of ethnicity on their expression remains unclear. We aimed to assess whether serum biomarker profiles differ among ethnic groups in a multinational PPCM cohort.
Methods and results: Eighty-two PPCM patients from seven countries in the EURObservational Research Programme (EORP) provided demographic data and serum samples. Ethnicity was self-reported. Proteomic profiling at diagnosis was performed using DIA-based label-free LC-MS, and data were analysed with Spectronaut v15. Ethnic variation was evaluated through principal component analysis (PCA). Participants had a mean age of 30.5 ± 6.7 years; 75% had no hypertension during pregnancy. Median LVEF was 35% (IQR 27.0-41.1), with no ethnic differences. Middle Eastern women showed more severe LV dilatation. PCA revealed no significant clustering by ethnicity; PC1 and PC2 explained 15.2% and 12.0% of variance, respectively.
Conclusions: QSOX1, ADIPOQ and ITIH3 exhibited consistent expressions across ethnic groups, supporting their use as universal PPCM biomarkers.
期刊介绍：
ESC Heart Failure is the open access journal of the Heart Failure Association of the European Society of Cardiology dedicated to the advancement of knowledge in the field of heart failure. The journal aims to improve the understanding, prevention, investigation and treatment of heart failure. Molecular and cellular biology, pathology, physiology, electrophysiology, pharmacology, as well as the clinical, social and population sciences all form part of the discipline that is heart failure. Accordingly, submission of manuscripts on basic, translational, clinical and population sciences is invited. Original contributions on nursing, care of the elderly, primary care, health economics and other specialist fields related to heart failure are also welcome, as are case reports that highlight interesting aspects of heart failure care and treatment.
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