微生物衍生的抗癌化合物:药物发现、生物工程和治疗应用的进展。

IF 3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Ekta Tyagi, Divya Jain, Rajabrata Bhuyan, Anand Prakash
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引用次数: 0

摘要

微生物代谢物是具有抗癌特性的生物活性化合物的重要来源。然而,传统的药物发现方法需要大量的时间和资源。方法:研究人工智能(AI)、机器学习(ML)、分子对接和定量构效关系(QSAR)建模在微生物代谢产物鉴定和优化中的作用。结果:人工智能驱动的方法显著增强了复方筛选和疗效预测。基于纳米载体的药物递送系统提高了微生物代谢物的生物利用度、特异性和稳定性,同时最大限度地减少了全身毒性。尽管取得了这些进展,但由于缺乏体内验证和全面的药代动力学数据,临床翻译仍然面临挑战。讨论:这篇综述强调了先进的计算工具和纳米技术在加速微生物衍生抗癌药物的发现和递送中的集成。结论:未来的发展方向是将人工智能与合成生物学相结合,设计能够产生增强生物活性化合物的微生物菌株。此外,利用纳米技术可以改进靶向递送机制。更深入地了解分子途径和耐药机制对于支持联合治疗的发展至关重要。总体而言,微生物衍生化合物在推进精准肿瘤学方面具有巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbial-Derived Anti-Cancer Compounds: Advances in Drug Discovery, Bioengineering, and Therapeutic Applications.

Introduction: Microbial metabolites represent a valuable source of bioactive compounds with promising anticancer properties. However, conventional drug discovery approaches are time-intensive and resource-demanding.

Methods: Recent developments in artificial intelligence (AI), machine learning (ML), molecular docking, and quantitative structure-activity relationship (QSAR) modeling have been examined for their role in the identification and optimization of microbial metabolites.

Results: AI-driven approaches have significantly enhanced compound screening and prediction of therapeutic efficacy. Nanocarrier-based drug delivery systems have improved the bioavailability, specificity, and stability of microbial metabolites while minimizing systemic toxicity. Despite these advancements, challenges remain in clinical translation due to the lack of in vivo validation and comprehensive pharmacokinetic data.

Discussion: This review highlights the integration of advanced computational tools and nanotechnology in accelerating the discovery and delivery of microbial-derived anticancer agents.

Conclusion: Future directions should focus on integrating AI with synthetic biology to engineer microbial strains capable of producing enhanced bioactive compounds. Additionally, leveraging nanotechnology could refine targeted delivery mechanisms. A deeper understanding of molecular pathways and drug resistance mechanisms is essential to support the development of combination therapies. Overall, microbialderived compounds hold substantial potential in advancing precision oncology.

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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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