{"title":"本文综述了法尼费罗C和伞形素抗癌活性的研究进展。","authors":"Reyhane Faghih, Mehrshad Talebi-Esmaeilan, Seyed Mahdi Mohamadi-Zarch, Seyyed Majid Bagheri","doi":"10.2174/0118715206380074250829111459","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer remains a growing challenge in modern society, presenting a significant obstacle in both developed and developing countries. Conventional treatments are often costly and limited by issues such as drug resistance and undesirable side effects. Consequently, the exploration of natural compounds has emerged as a promising strategy for developing more effective and tolerable cancer therapies. Among these, Ferula plants have gained attention for their potential anticancer components. Notably, two coumarin compounds derived from these plants, farnesiferol C and umbelliferone, have demonstrated substantial anticancer activity, as supported by an increasing number of published studies. This review aims to consolidate existing evidence on the anticancer effects of farnesiferol C and umbelliferone while comparing their efficacy as potential therapeutic agents. To accomplish this, a comprehensive literature search was conducted using the terms \"umbelliferone\" and \"farnesiferol C\" paired with \"anticancer\" across databases such as ISI Web of Knowledge, PubMed, and Google Scholar. Relevant studies up to March 2024 were retrieved, summarized, and incorporated into this analysis. The findings indicate that both compounds exhibit significant anticancer properties, positioning them as viable candidates for future drug development. A comparative analysis of their IC50 values, the concentration required to inhibit 50% of cancer cell growth, reveals that farnesiferol C demonstrates greater cytotoxic potency against various cancer cell lines compared to umbelliferone. However, while these results are encouraging, further research is recommended, particularly in vivo studies to evaluate the compounds' toxicity and therapeutic potential in living organisms.</p>","PeriodicalId":7934,"journal":{"name":"Anti-cancer agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Narrative Review Article A Comprehensive Review of the Anticancer Activity of Farnesiferol C and Umbelliferone.\",\"authors\":\"Reyhane Faghih, Mehrshad Talebi-Esmaeilan, Seyed Mahdi Mohamadi-Zarch, Seyyed Majid Bagheri\",\"doi\":\"10.2174/0118715206380074250829111459\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cancer remains a growing challenge in modern society, presenting a significant obstacle in both developed and developing countries. 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引用次数: 0
摘要
癌症仍然是现代社会日益严重的挑战,在发达国家和发展中国家都是一个重大障碍。传统的治疗方法往往很昂贵,而且受到诸如耐药性和不良副作用等问题的限制。因此,探索天然化合物已成为开发更有效和可耐受的癌症治疗方法的一种有前途的策略。其中,阿魏属植物因其潜在的抗癌成分而受到关注。值得注意的是,从这些植物中提取的两种香豆素化合物,法尼铁酚C和伞花素,已经证明了大量的抗癌活性,这得到了越来越多已发表的研究的支持。本综述旨在巩固法尼弗罗C和伞形酮抗癌作用的现有证据,并比较它们作为潜在治疗药物的疗效。为了完成这项工作,我们在ISI Web of Knowledge、PubMed和谷歌Scholar等数据库中使用术语“umbellliferone”和“farnesiferol C”与“抗癌”配对进行了全面的文献检索。检索到2024年3月的相关研究,汇总并纳入本分析。研究结果表明,这两种化合物都表现出显著的抗癌特性,使它们成为未来药物开发的可行候选者。对它们的IC50值(抑制50%癌细胞生长所需的浓度)的比较分析表明,与伞形素相比,法尼弗醇C对各种癌细胞系具有更强的细胞毒性。然而,虽然这些结果令人鼓舞,但建议进一步研究,特别是在活体研究中评估化合物的毒性和治疗潜力。
Narrative Review Article A Comprehensive Review of the Anticancer Activity of Farnesiferol C and Umbelliferone.
Cancer remains a growing challenge in modern society, presenting a significant obstacle in both developed and developing countries. Conventional treatments are often costly and limited by issues such as drug resistance and undesirable side effects. Consequently, the exploration of natural compounds has emerged as a promising strategy for developing more effective and tolerable cancer therapies. Among these, Ferula plants have gained attention for their potential anticancer components. Notably, two coumarin compounds derived from these plants, farnesiferol C and umbelliferone, have demonstrated substantial anticancer activity, as supported by an increasing number of published studies. This review aims to consolidate existing evidence on the anticancer effects of farnesiferol C and umbelliferone while comparing their efficacy as potential therapeutic agents. To accomplish this, a comprehensive literature search was conducted using the terms "umbelliferone" and "farnesiferol C" paired with "anticancer" across databases such as ISI Web of Knowledge, PubMed, and Google Scholar. Relevant studies up to March 2024 were retrieved, summarized, and incorporated into this analysis. The findings indicate that both compounds exhibit significant anticancer properties, positioning them as viable candidates for future drug development. A comparative analysis of their IC50 values, the concentration required to inhibit 50% of cancer cell growth, reveals that farnesiferol C demonstrates greater cytotoxic potency against various cancer cell lines compared to umbelliferone. However, while these results are encouraging, further research is recommended, particularly in vivo studies to evaluate the compounds' toxicity and therapeutic potential in living organisms.
期刊介绍:
Formerly: Current Medicinal Chemistry - Anti-Cancer Agents.
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.
Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.