{"title":"长链非编码RNA VPS9D1-AS1在人类癌症中的作用、机制和临床应用","authors":"Jingjie Yang, Haodong He, Haoran Liu, Zhouya Xu, Li Li, Houdong Li, Chengfu Yuan","doi":"10.2174/0118715206400852250818061543","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>VPS9 domain-containing 1 antisense RNA 1 (VPS9D1-AS1), also known as c-Mycupregulated lncRNA (MYU) and FAK-interacting and stabilizing lncRNA (FAISL), is a novel long non-coding RNA (lncRNA) located at the human chromosome 16q24.3 locus. It has been reported to be highly expressed in various human cancers and associated with poor clinical pathological features and unfavorable prognosis in eight of the malignant tumors.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using PubMed, Web of Science, and Google Scholar databases to identify relevant articles on \"VPS9D1-AS1\", \"MYU\", or \"FAISL\". Only peer-reviewed publications were included, and articles related to oncology were specifically collected.</p><p><strong>Results: </strong>Mechanistically, VPS9D1-AS1 serves as a key regulator in four molecular models: signal, scaffold, guide, and decoy. These functions allow it to regulate the expression of target genes and activation of signaling pathways, thereby influencing the malignant phenotype of tumors.</p><p><strong>Discussion: </strong>The diverse molecular mechanisms of VPS9D1-AS1 highlight its significant role in the development and progression of various cancers. Its ability to act as a signal, scaffold, guide, and decoy suggests that it can influence multiple aspects of tumor biology, including proliferation, invasion, and metastasis.</p><p><strong>Conclusion: </strong>VPS9D1-AS1 plays a significant role in the development and progression of various cancers through its diverse molecular mechanisms. Further research on VPS9D1-AS1 may provide valuable insights, which may facilitate the development of new diagnostic and therapeutic strategies for cancer.</p>","PeriodicalId":7934,"journal":{"name":"Anti-cancer agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long Non-Coding RNA VPS9D1-AS1 in Human Cancer: Functions, Mechanisms, and Clinical Utility.\",\"authors\":\"Jingjie Yang, Haodong He, Haoran Liu, Zhouya Xu, Li Li, Houdong Li, Chengfu Yuan\",\"doi\":\"10.2174/0118715206400852250818061543\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>VPS9 domain-containing 1 antisense RNA 1 (VPS9D1-AS1), also known as c-Mycupregulated lncRNA (MYU) and FAK-interacting and stabilizing lncRNA (FAISL), is a novel long non-coding RNA (lncRNA) located at the human chromosome 16q24.3 locus. It has been reported to be highly expressed in various human cancers and associated with poor clinical pathological features and unfavorable prognosis in eight of the malignant tumors.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using PubMed, Web of Science, and Google Scholar databases to identify relevant articles on \\\"VPS9D1-AS1\\\", \\\"MYU\\\", or \\\"FAISL\\\". Only peer-reviewed publications were included, and articles related to oncology were specifically collected.</p><p><strong>Results: </strong>Mechanistically, VPS9D1-AS1 serves as a key regulator in four molecular models: signal, scaffold, guide, and decoy. These functions allow it to regulate the expression of target genes and activation of signaling pathways, thereby influencing the malignant phenotype of tumors.</p><p><strong>Discussion: </strong>The diverse molecular mechanisms of VPS9D1-AS1 highlight its significant role in the development and progression of various cancers. Its ability to act as a signal, scaffold, guide, and decoy suggests that it can influence multiple aspects of tumor biology, including proliferation, invasion, and metastasis.</p><p><strong>Conclusion: </strong>VPS9D1-AS1 plays a significant role in the development and progression of various cancers through its diverse molecular mechanisms. Further research on VPS9D1-AS1 may provide valuable insights, which may facilitate the development of new diagnostic and therapeutic strategies for cancer.</p>\",\"PeriodicalId\":7934,\"journal\":{\"name\":\"Anti-cancer agents in medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anti-cancer agents in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0118715206400852250818061543\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anti-cancer agents in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0118715206400852250818061543","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
简介:VPS9结构域1反义RNA 1 (VPS9D1-AS1),又称c- mycu调控lncRNA (MYU)和fak相互作用和稳定lncRNA (FAISL),是一种位于人类染色体16q24.3位点的新型长链非编码RNA (lncRNA)。据报道,它在各种人类癌症中高表达,并与八种恶性肿瘤的临床病理特征差和预后不良相关。方法:采用PubMed、Web of Science和b谷歌Scholar数据库进行综合文献检索,在“VPS9D1-AS1”、“MYU”或“FAISL”上检索相关文章。仅纳入同行评审的出版物,并专门收集与肿瘤学相关的文章。结果:从机制上讲,VPS9D1-AS1在信号、支架、引导和诱饵四种分子模型中起关键调节作用。这些功能使其能够调控靶基因的表达和信号通路的激活,从而影响肿瘤的恶性表型。讨论:VPS9D1-AS1不同的分子机制凸显了其在多种癌症发生发展中的重要作用。它作为信号、支架、引导和诱饵的能力表明,它可以影响肿瘤生物学的多个方面,包括增殖、侵袭和转移。结论:VPS9D1-AS1通过其多样的分子机制在多种癌症的发生发展中发挥重要作用。对VPS9D1-AS1的进一步研究可能会提供有价值的见解,这可能有助于开发新的癌症诊断和治疗策略。
Long Non-Coding RNA VPS9D1-AS1 in Human Cancer: Functions, Mechanisms, and Clinical Utility.
Introduction: VPS9 domain-containing 1 antisense RNA 1 (VPS9D1-AS1), also known as c-Mycupregulated lncRNA (MYU) and FAK-interacting and stabilizing lncRNA (FAISL), is a novel long non-coding RNA (lncRNA) located at the human chromosome 16q24.3 locus. It has been reported to be highly expressed in various human cancers and associated with poor clinical pathological features and unfavorable prognosis in eight of the malignant tumors.
Methods: A comprehensive literature search was conducted using PubMed, Web of Science, and Google Scholar databases to identify relevant articles on "VPS9D1-AS1", "MYU", or "FAISL". Only peer-reviewed publications were included, and articles related to oncology were specifically collected.
Results: Mechanistically, VPS9D1-AS1 serves as a key regulator in four molecular models: signal, scaffold, guide, and decoy. These functions allow it to regulate the expression of target genes and activation of signaling pathways, thereby influencing the malignant phenotype of tumors.
Discussion: The diverse molecular mechanisms of VPS9D1-AS1 highlight its significant role in the development and progression of various cancers. Its ability to act as a signal, scaffold, guide, and decoy suggests that it can influence multiple aspects of tumor biology, including proliferation, invasion, and metastasis.
Conclusion: VPS9D1-AS1 plays a significant role in the development and progression of various cancers through its diverse molecular mechanisms. Further research on VPS9D1-AS1 may provide valuable insights, which may facilitate the development of new diagnostic and therapeutic strategies for cancer.
期刊介绍:
Formerly: Current Medicinal Chemistry - Anti-Cancer Agents.
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.
Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.