温度自动控制FAIMS芯片的实验与仿真研究。

IF 2.7 2区 化学 Q2 BIOCHEMICAL RESEARCH METHODS
Xiaoxia Du, , , Haonan Liang, , , Yao Li, , , Xingxing A Luo, , , Yuqiao Zhang, , and , Hua Li*, 
{"title":"温度自动控制FAIMS芯片的实验与仿真研究。","authors":"Xiaoxia Du,&nbsp;, ,&nbsp;Haonan Liang,&nbsp;, ,&nbsp;Yao Li,&nbsp;, ,&nbsp;Xingxing A Luo,&nbsp;, ,&nbsp;Yuqiao Zhang,&nbsp;, and ,&nbsp;Hua Li*,&nbsp;","doi":"10.1021/jasms.4c00427","DOIUrl":null,"url":null,"abstract":"<p >The temperature of the carrier gas will affect the performance of high-field asymmetric ion waveform mobility spectrometry (FAIMS), changing the height and position of the peaks of the FAIMS spectrum. In this study, we explored the influence of temperature on the FAIMS spectrum through experiment and simulation. In the experiment, the PCB self-heating temperature control FAIMS system was used to study the effects of temperature changes on the FAIMS spectra of ethanol, acetic acid, acetone, and ethyl acetate, and the coefficient solving methods of mobility <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were derived in detail. Based on the experimental data, the mobility coefficients <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were solved and replaced by the simulation software SIMION. The results show that as the temperature increases, the peak height of the spectrum of FAIMS decreases, and there will be a certain amount of offset in the position of the peaks in the spectrum. Through simulation, it is found that during the heating process, the number of ions decreases from approximately 60 to 6, and the compensation voltages of acetone, ethanol, acetic acid, and ethyl acetate change by about 1.1, 0.7, 0.3, and 0.1 V, respectively. This study provides a detailed solution process for the calculation of the ion mobility coefficients in the SIMION simulation, and the use of temperature control can effectively improve the resolution and accuracy of FAIMS in volatile organic compounds (VOCs) detection.</p>","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 10","pages":"2026–2035"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Experiment and Simulation Study of Automatic Temperature Control FAIMS Chip\",\"authors\":\"Xiaoxia Du,&nbsp;, ,&nbsp;Haonan Liang,&nbsp;, ,&nbsp;Yao Li,&nbsp;, ,&nbsp;Xingxing A Luo,&nbsp;, ,&nbsp;Yuqiao Zhang,&nbsp;, and ,&nbsp;Hua Li*,&nbsp;\",\"doi\":\"10.1021/jasms.4c00427\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The temperature of the carrier gas will affect the performance of high-field asymmetric ion waveform mobility spectrometry (FAIMS), changing the height and position of the peaks of the FAIMS spectrum. In this study, we explored the influence of temperature on the FAIMS spectrum through experiment and simulation. In the experiment, the PCB self-heating temperature control FAIMS system was used to study the effects of temperature changes on the FAIMS spectra of ethanol, acetic acid, acetone, and ethyl acetate, and the coefficient solving methods of mobility <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were derived in detail. Based on the experimental data, the mobility coefficients <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were solved and replaced by the simulation software SIMION. The results show that as the temperature increases, the peak height of the spectrum of FAIMS decreases, and there will be a certain amount of offset in the position of the peaks in the spectrum. Through simulation, it is found that during the heating process, the number of ions decreases from approximately 60 to 6, and the compensation voltages of acetone, ethanol, acetic acid, and ethyl acetate change by about 1.1, 0.7, 0.3, and 0.1 V, respectively. This study provides a detailed solution process for the calculation of the ion mobility coefficients in the SIMION simulation, and the use of temperature control can effectively improve the resolution and accuracy of FAIMS in volatile organic compounds (VOCs) detection.</p>\",\"PeriodicalId\":672,\"journal\":{\"name\":\"Journal of the American Society for Mass Spectrometry\",\"volume\":\"36 10\",\"pages\":\"2026–2035\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Society for Mass Spectrometry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/jasms.4c00427\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Society for Mass Spectrometry","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/jasms.4c00427","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

摘要

载气的温度会影响高场不对称离子波形迁移率光谱(FAIMS)的性能,改变FAIMS光谱峰的高度和位置。在本研究中,我们通过实验和模拟探讨了温度对FAIMS光谱的影响。实验采用PCB自热温控FAIMS系统,研究了温度变化对乙醇、乙酸、丙酮和乙酸乙酯FAIMS光谱的影响,详细推导了迁移率a2和a4的系数求解方法。在实验数据的基础上,利用仿真软件SIMION对迁移系数a2和a4进行求解和替换。结果表明,随着温度的升高,FAIMS光谱的峰高降低,光谱中峰的位置会出现一定的偏移。通过模拟发现,在加热过程中,离子数量从大约60个减少到6个,丙酮、乙醇、乙酸和乙酸乙酯的补偿电压分别变化约1.1、0.7、0.3和0.1 V。本研究为SIMION模拟中离子迁移系数的计算提供了详细的求解过程,利用温度控制可以有效提高FAIMS在挥发性有机化合物(VOCs)检测中的分辨率和精度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Experiment and Simulation Study of Automatic Temperature Control FAIMS Chip

Experiment and Simulation Study of Automatic Temperature Control FAIMS Chip

The temperature of the carrier gas will affect the performance of high-field asymmetric ion waveform mobility spectrometry (FAIMS), changing the height and position of the peaks of the FAIMS spectrum. In this study, we explored the influence of temperature on the FAIMS spectrum through experiment and simulation. In the experiment, the PCB self-heating temperature control FAIMS system was used to study the effects of temperature changes on the FAIMS spectra of ethanol, acetic acid, acetone, and ethyl acetate, and the coefficient solving methods of mobility a2 and a4 were derived in detail. Based on the experimental data, the mobility coefficients a2 and a4 were solved and replaced by the simulation software SIMION. The results show that as the temperature increases, the peak height of the spectrum of FAIMS decreases, and there will be a certain amount of offset in the position of the peaks in the spectrum. Through simulation, it is found that during the heating process, the number of ions decreases from approximately 60 to 6, and the compensation voltages of acetone, ethanol, acetic acid, and ethyl acetate change by about 1.1, 0.7, 0.3, and 0.1 V, respectively. This study provides a detailed solution process for the calculation of the ion mobility coefficients in the SIMION simulation, and the use of temperature control can effectively improve the resolution and accuracy of FAIMS in volatile organic compounds (VOCs) detection.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
5.50
自引率
9.40%
发文量
257
审稿时长
1 months
期刊介绍: The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role. Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信