Xiaoxia Du, , , Haonan Liang, , , Yao Li, , , Xingxing A Luo, , , Yuqiao Zhang, , and , Hua Li*,
{"title":"温度自动控制FAIMS芯片的实验与仿真研究。","authors":"Xiaoxia Du, , , Haonan Liang, , , Yao Li, , , Xingxing A Luo, , , Yuqiao Zhang, , and , Hua Li*, ","doi":"10.1021/jasms.4c00427","DOIUrl":null,"url":null,"abstract":"<p >The temperature of the carrier gas will affect the performance of high-field asymmetric ion waveform mobility spectrometry (FAIMS), changing the height and position of the peaks of the FAIMS spectrum. In this study, we explored the influence of temperature on the FAIMS spectrum through experiment and simulation. In the experiment, the PCB self-heating temperature control FAIMS system was used to study the effects of temperature changes on the FAIMS spectra of ethanol, acetic acid, acetone, and ethyl acetate, and the coefficient solving methods of mobility <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were derived in detail. Based on the experimental data, the mobility coefficients <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were solved and replaced by the simulation software SIMION. The results show that as the temperature increases, the peak height of the spectrum of FAIMS decreases, and there will be a certain amount of offset in the position of the peaks in the spectrum. Through simulation, it is found that during the heating process, the number of ions decreases from approximately 60 to 6, and the compensation voltages of acetone, ethanol, acetic acid, and ethyl acetate change by about 1.1, 0.7, 0.3, and 0.1 V, respectively. This study provides a detailed solution process for the calculation of the ion mobility coefficients in the SIMION simulation, and the use of temperature control can effectively improve the resolution and accuracy of FAIMS in volatile organic compounds (VOCs) detection.</p>","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 10","pages":"2026–2035"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Experiment and Simulation Study of Automatic Temperature Control FAIMS Chip\",\"authors\":\"Xiaoxia Du, , , Haonan Liang, , , Yao Li, , , Xingxing A Luo, , , Yuqiao Zhang, , and , Hua Li*, \",\"doi\":\"10.1021/jasms.4c00427\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The temperature of the carrier gas will affect the performance of high-field asymmetric ion waveform mobility spectrometry (FAIMS), changing the height and position of the peaks of the FAIMS spectrum. In this study, we explored the influence of temperature on the FAIMS spectrum through experiment and simulation. In the experiment, the PCB self-heating temperature control FAIMS system was used to study the effects of temperature changes on the FAIMS spectra of ethanol, acetic acid, acetone, and ethyl acetate, and the coefficient solving methods of mobility <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were derived in detail. Based on the experimental data, the mobility coefficients <i>a</i><sub>2</sub> and <i>a</i><sub>4</sub> were solved and replaced by the simulation software SIMION. The results show that as the temperature increases, the peak height of the spectrum of FAIMS decreases, and there will be a certain amount of offset in the position of the peaks in the spectrum. Through simulation, it is found that during the heating process, the number of ions decreases from approximately 60 to 6, and the compensation voltages of acetone, ethanol, acetic acid, and ethyl acetate change by about 1.1, 0.7, 0.3, and 0.1 V, respectively. This study provides a detailed solution process for the calculation of the ion mobility coefficients in the SIMION simulation, and the use of temperature control can effectively improve the resolution and accuracy of FAIMS in volatile organic compounds (VOCs) detection.</p>\",\"PeriodicalId\":672,\"journal\":{\"name\":\"Journal of the American Society for Mass Spectrometry\",\"volume\":\"36 10\",\"pages\":\"2026–2035\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Society for Mass Spectrometry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/jasms.4c00427\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Society for Mass Spectrometry","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/jasms.4c00427","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Experiment and Simulation Study of Automatic Temperature Control FAIMS Chip
The temperature of the carrier gas will affect the performance of high-field asymmetric ion waveform mobility spectrometry (FAIMS), changing the height and position of the peaks of the FAIMS spectrum. In this study, we explored the influence of temperature on the FAIMS spectrum through experiment and simulation. In the experiment, the PCB self-heating temperature control FAIMS system was used to study the effects of temperature changes on the FAIMS spectra of ethanol, acetic acid, acetone, and ethyl acetate, and the coefficient solving methods of mobility a2 and a4 were derived in detail. Based on the experimental data, the mobility coefficients a2 and a4 were solved and replaced by the simulation software SIMION. The results show that as the temperature increases, the peak height of the spectrum of FAIMS decreases, and there will be a certain amount of offset in the position of the peaks in the spectrum. Through simulation, it is found that during the heating process, the number of ions decreases from approximately 60 to 6, and the compensation voltages of acetone, ethanol, acetic acid, and ethyl acetate change by about 1.1, 0.7, 0.3, and 0.1 V, respectively. This study provides a detailed solution process for the calculation of the ion mobility coefficients in the SIMION simulation, and the use of temperature control can effectively improve the resolution and accuracy of FAIMS in volatile organic compounds (VOCs) detection.
期刊介绍:
The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role.
Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives