卵泡液中血小板因子4水平升高与多囊卵巢综合征有关

IF 2.1 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinical biochemistry Pub Date : 2025-09-03 DOI:10.1016/j.clinbiochem.2025.111009

Wenqi Wang , Guangxi Wang , Xiaoming Niu , Zhonglan Li , Mingfu Zhang , Zhenchao Xu , Tou Liu

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引用次数: 0

摘要

目的测定多囊卵巢综合征（PCOS）患者卵泡液中血小板因子4 （PF4）蛋白水平，并分析PF4蛋白水平与临床特征的相关性。方法67例女性（PCOS患者36例，非PCOS患者31例）纳入研究。采用酶联免疫吸附法分析卵泡液PF4水平。结果PCOS患者卵泡液中PF4水平明显高于非PCOS对照组(50.5 （95% CI: 42.8 ~ 115.86) ng/ml vs. 37.42 (95% CI: 23.01 ~ 49.69) ng/ml, p < 0.001）。相关分析显示，PF4水平与所有患者血清抗苗勒管激素（r = 0.3809, p = 0.0015）、血清睾酮（r = 0.3629, p = 0.0025）、窦卵泡计数（r = 0.5544, p < 0.0001）、取卵数（r = 0.3799, p = 0.0018）呈正相关。卵泡液PF4水平预测PCOS的曲线下面积为0.723 （95% CI: 0.600 ~ 0.847）。结论PCOS患者卵泡液中PF4水平升高，与PCOS的关键特征相关，提示PF4可能在PCOS的发病机制中发挥作用。

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Elevated level of platelet factor 4 in follicular fluid is associated with polycystic ovary syndrome

Objective

This present study aimed to measure platelet factor 4 (PF4) protein level in follicular fluid of patients with polycystic ovary syndrome (PCOS) and analyzed the correlation between follicular PF4 level with clinical characteristics.

Methods

Sixty-seven women (36 PCOS patients vs. 31 non-PCOS women) were enrolled in the study. Follicular fluid PF4 level was analyzed by enzyme-linked immunosorbent assay.

Results

The level of PF4 was significantly higher in follicular fluid of patients with PCOS than that of non-PCOS controls (50.5 (95 % CI: 42.8 to 115.86) ng/ml vs. 37.42 (95 % CI: 23.01 to 49.69) ng/ml, p < 0.001). Correlation analysis showed that the level of PF4 was positively related with serum anti-Mullerian hormone (r = 0.3809, p = 0.0015), serum testosterone (r = 0.3629, p = 0.0025), antral follicle count (r = 0.5544, p < 0.0001), and number of oocytes retrieved (r = 0.3799, p = 0.0018) in all patients. The area under the curve of PF4 level in follicular fluid to predict PCOS was 0.723 (95 % CI: 0.600 to 0.847).

Conclusions

Our study demonstrated that the PF4 level was higher in the follicular fluid of patients with PCOS and was associated with key features of PCOS, suggesting that PF4 may play a role in the pathogenesis of PCOS.

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来源期刊

Clinical biochemistry 医学-医学实验技术

CiteScore

5.10

自引率

0.00%

发文量

151

审稿时长

25 days

期刊介绍： Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.