有机光氧化还原级联环化合成硅基/氟烷基化四环吡咯利二酮。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-05 DOI:10.1021/acs.orglett.5c03180

Fengqian Liu, Guoqin Wang, Shasha Wang, Zhengbing Zhang, Dan Yang*, Pan Han* and Linhai Jing*,

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引用次数: 0

摘要

在氧化还原-中性条件下，以氢硅烷或氟烷基亚硫酸盐为自由基源，通过可见光诱导的3-亚甲基异吲哚-1- 1级联环化，获得了前所未有的硅基/氟烷基包埋四环吡咯利二酮的新策略。该方案具有反应条件温和、操作简单、与各种官能团相容性好等特点。大量硅基/氟甲基修饰的四环吡咯烷二酮骨架被高效地合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Organophotoredox Cascade Cyclization for the Synthesis of Silyl/Fluoroalkylated Tetracyclic Pyrrolizidinediones

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Organophotoredox Cascade Cyclization for the Synthesis of Silyl/Fluoroalkylated Tetracyclic Pyrrolizidinediones

A novel strategy for accessing unprecedented silyl/fluoroalkyl-embedded tetracyclic pyrrolizidinediones has been developed through the visible-light-induced cascade cyclization of 3-methyleneisoindolin-1-ones using hydrosilanes or fluoroalkylsulfinate salts as radical sources under redox-neutral conditions. This protocol features mild reaction conditions, operational simplicity, and excellent compatibility with various functional groups. A number of silyl/fluoromethyl-decorated tetracyclic pyrrolizidinedione frameworks were efficiently created.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.