Iron metabolism and sepsis-associated liver injury: Methodological considerations and clinical perspectives.

This letter offered commentary on the recently published article by Wang et al that investigated the relationship between iron metabolism disorders and sepsis-associated liver injury (SALI). The original study identified serum iron and total iron-binding capacity as potential predictive markers of SALI, contributing important insights to critical care hepatology. In this correspondence several methodological considerations that may influence the interpretation and generalizability of the findings were discussed. These include the limitations of a single-center design, the lack of serial biomarker measurements, the omission of hepcidin (a central iron regulatory hormone) as a measured variable, and the exclusive reliance on biochemical criteria for diagnosing liver injury. The potential value of incorporating imaging modalities and additional iron-related markers such as ferritin and transferrin saturation were also highlighted. The aim was to reinforce the importance of a comprehensive approach to iron metabolism in sepsis and to suggest future directions for clinical research that may enhance the diagnostic and prognostic utility of iron-related biomarkers in SALI.