Sang-Il Lee, Jin-Gyu Jung, In Ae Chang, Eun-Heui Jin, Jang Hee Hong
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This case-control study aimed to evaluate the association between SNPs in <i>ANRIL</i>, GC risk, and subgroups in a Korean population. <b><i>Methodology:</i></b> The TaqMan genotyping assay of six SNPs in <i>ANRIL</i> was performed in 419 patients with GC and 348 controls. <b><i>Results:</i></b> After adjusting for age and gender, the following significant associations were identified: rs2157719 in the dominant model (TC+CC vs. TT) with decreased GC risk in the lymph node metastasis (LNM)-negative subgroup (<i>p</i> = 0.045, adjusted odds ratio [AOR] = 0.65, 95% confidence interval [CI] = 0.43-0.99); rs1333040 in the recessive model (CC vs. TT+TC) with increased risk in the undifferentiated subgroup (<i>p</i> = 0.032, AOR = 1.92, 95% CI = 1.06-3.50); and rs4977574 in the dominant model (AG+GG vs. AA) with decreased risk in the LNM-positive, tumor stage III (A+B+C), and undifferentiated subgroups (<i>p</i> = 0.007, AOR = 0.58, 95% CI = 0.39-0.86; <i>p</i> = 0.028, AOR = 0.63, 95% CI = 0.42-0.95; and <i>p</i> = 0.049, AOR = 0.63, 95% CI = 0.40-1.00, respectively). <b><i>Conclusion:</i></b> Our findings suggest that these SNPs in <i>ANRIL</i> are associated with GC risk and influence GC development. Further studies are needed to confirm our results in different ethnic groups and larger populations.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":" ","pages":"233-240"},"PeriodicalIF":1.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genetic Association Between Polymorphisms in lncRNA <i>ANRIL</i> and Gastric Cancer Susceptibility.\",\"authors\":\"Sang-Il Lee, Jin-Gyu Jung, In Ae Chang, Eun-Heui Jin, Jang Hee Hong\",\"doi\":\"10.1177/19450265251375929\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b><i>Objective:</i></b> Genetic variations of long noncoding RNAs are potential biomarkers for gastric cancer (GC). However, reports on the association between single nucleotide polymorphisms (SNPs) in antisense noncoding RNA in the INK4 locus (<i>ANRIL</i>) and GC risk are few. This case-control study aimed to evaluate the association between SNPs in <i>ANRIL</i>, GC risk, and subgroups in a Korean population. <b><i>Methodology:</i></b> The TaqMan genotyping assay of six SNPs in <i>ANRIL</i> was performed in 419 patients with GC and 348 controls. <b><i>Results:</i></b> After adjusting for age and gender, the following significant associations were identified: rs2157719 in the dominant model (TC+CC vs. TT) with decreased GC risk in the lymph node metastasis (LNM)-negative subgroup (<i>p</i> = 0.045, adjusted odds ratio [AOR] = 0.65, 95% confidence interval [CI] = 0.43-0.99); rs1333040 in the recessive model (CC vs. TT+TC) with increased risk in the undifferentiated subgroup (<i>p</i> = 0.032, AOR = 1.92, 95% CI = 1.06-3.50); and rs4977574 in the dominant model (AG+GG vs. AA) with decreased risk in the LNM-positive, tumor stage III (A+B+C), and undifferentiated subgroups (<i>p</i> = 0.007, AOR = 0.58, 95% CI = 0.39-0.86; <i>p</i> = 0.028, AOR = 0.63, 95% CI = 0.42-0.95; and <i>p</i> = 0.049, AOR = 0.63, 95% CI = 0.40-1.00, respectively). <b><i>Conclusion:</i></b> Our findings suggest that these SNPs in <i>ANRIL</i> are associated with GC risk and influence GC development. Further studies are needed to confirm our results in different ethnic groups and larger populations.</p>\",\"PeriodicalId\":12603,\"journal\":{\"name\":\"Genetic testing and molecular biomarkers\",\"volume\":\" \",\"pages\":\"233-240\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genetic testing and molecular biomarkers\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1177/19450265251375929\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genetic testing and molecular biomarkers","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1177/19450265251375929","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/3 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
摘要
目的:长链非编码rna的遗传变异是胃癌的潜在生物标志物。然而,关于INK4位点(ANRIL)反义非编码RNA单核苷酸多态性(snp)与GC风险之间关系的报道很少。本病例对照研究旨在评估韩国人群中ANRIL、GC风险和亚组snp之间的关系。方法:对419例胃癌患者和348例对照组进行ANRIL 6个snp的TaqMan基因分型分析。结果:在调整年龄和性别后,发现了以下显著相关性:优势模型(TC+CC vs. TT)中rs2157719与淋巴结转移(LNM)阴性亚组GC风险降低相关(p = 0.045,校正优势比[AOR] = 0.65, 95%可信区间[CI] = 0.43-0.99);rs1333040在隐性模型(CC vs TT+TC)中与未分化亚组的风险增加(p = 0.032, AOR = 1.92, 95% CI = 1.06-3.50);在lnm阳性、肿瘤期(A+B+C)和未分化亚组(p = 0.007, AOR = 0.58, 95% CI = 0.42-0.95; p = 0.028, AOR = 0.63, 95% CI = 0.42-0.95; p = 0.049, AOR = 0.63, 95% CI = 0.40-1.00)中,rs4977574和rs4977574在优势模型(AG+GG vs. AA)中的风险降低。结论:我们的研究结果表明,ANRIL中的这些snp与胃癌风险相关,并影响胃癌的发展。需要进一步的研究来证实我们在不同种族群体和更大人群中的结果。
Genetic Association Between Polymorphisms in lncRNA ANRIL and Gastric Cancer Susceptibility.
Objective: Genetic variations of long noncoding RNAs are potential biomarkers for gastric cancer (GC). However, reports on the association between single nucleotide polymorphisms (SNPs) in antisense noncoding RNA in the INK4 locus (ANRIL) and GC risk are few. This case-control study aimed to evaluate the association between SNPs in ANRIL, GC risk, and subgroups in a Korean population. Methodology: The TaqMan genotyping assay of six SNPs in ANRIL was performed in 419 patients with GC and 348 controls. Results: After adjusting for age and gender, the following significant associations were identified: rs2157719 in the dominant model (TC+CC vs. TT) with decreased GC risk in the lymph node metastasis (LNM)-negative subgroup (p = 0.045, adjusted odds ratio [AOR] = 0.65, 95% confidence interval [CI] = 0.43-0.99); rs1333040 in the recessive model (CC vs. TT+TC) with increased risk in the undifferentiated subgroup (p = 0.032, AOR = 1.92, 95% CI = 1.06-3.50); and rs4977574 in the dominant model (AG+GG vs. AA) with decreased risk in the LNM-positive, tumor stage III (A+B+C), and undifferentiated subgroups (p = 0.007, AOR = 0.58, 95% CI = 0.39-0.86; p = 0.028, AOR = 0.63, 95% CI = 0.42-0.95; and p = 0.049, AOR = 0.63, 95% CI = 0.40-1.00, respectively). Conclusion: Our findings suggest that these SNPs in ANRIL are associated with GC risk and influence GC development. Further studies are needed to confirm our results in different ethnic groups and larger populations.
期刊介绍:
Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results.
Genetic Testing and Molecular Biomarkers coverage includes:
-Diagnosis across the life span-
Risk assessment-
Carrier detection in individuals, couples, and populations-
Novel methods and new instrumentation for genetic testing-
Results of molecular, biochemical, and cytogenetic testing-
Genetic counseling