主要呼吸道病毒感染累及肝脏。

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY
Clinical and Experimental Hepatology Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI:10.5114/ceh.2025.151800
Piotr Rzymski, Krystyna Dobrowolska, Michał Brzdęk, Dorota Zarębska-Michaluk, Robert Flisiak
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引用次数: 0

摘要

常见的呼吸道病毒病原体,包括SARS-CoV-2、流感病毒和呼吸道合胞病毒(RSV),可导致肺外表现,包括临床显著的肝脏受累。这篇综述综合了与这些病毒相关的肝损伤的流行病学、机制和预后意义的现有证据。我们讨论了肝功能障碍的不同机制,从肝细胞直接病毒感染的可能性到全身炎症反应的间接影响、缺氧损伤、先前存在的肝脏疾病和药物相关的肝毒性。与流感或呼吸道合胞病毒感染相比,对COVID-19对肝脏的影响的探索程度要大得多,这凸显了进一步研究的必要性。在临床上,认识到呼吸道病毒感染对肝脏的影响是至关重要的,特别是在慢性肝病患者、移植受者和儿童等高危人群中。我们强调将肝脏评估纳入严重呼吸道病毒性疾病的临床方法以改善患者预后的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hepatic involvement in major respiratory viral infections.

Common respiratory viral pathogens, including SARS-CoV-2, influenza viruses, and respiratory syncytial virus (RSV), can lead to extrapulmonary manifestations, including clinically significant liver involvement. This review synthesizes current evidence on the epidemiology, mechanisms, and prognostic implications of hepatic injury associated with these viruses. We discuss the distinct mechanisms of liver dysfunction, ranging from the possibility of direct viral infection of hepatocytes to indirect effects of systemic inflammatory responses, hypoxic injury, preexisting liver disease, and drug-related hepatotoxicity. Liver involvement in COVID-19 has been explored to a much greater extent than in the case of influenza or RSV infections, highlighting the need for further studies. Clinically, recognizing liver involvement in respiratory viral infections is crucial, particularly in high-risk populations such as patients with chronic liver disease, transplant recipients, and children. We underscore the importance of integrating hepatic evaluation into the clinical approach to severe respiratory viral illnesses to improve patient outcomes.

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来源期刊
Clinical and Experimental Hepatology
Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.80
自引率
0.00%
发文量
32
期刊介绍: Clinical and Experimental Hepatology – quarterly of the Polish Association for Study of Liver – is a scientific and educational, peer-reviewed journal publishing original and review papers describing clinical and basic investigations in the field of hepatology.
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