心脏组织工程的最新进展：创新和未来方向

IF 3.1 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Biotechnology Journal Pub Date : 2025-09-05 DOI:10.1002/biot.70116

Adnan Taan Al khafaji, Ali Mohammed Barakat, Akram jooda Al Zaidy, Ali Adnan Taan, Raed Fanoukh Aboqader Al-Aouadi

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引用次数: 0

摘要

心脏组织工程（CTE）是一个快速发展的领域，它结合了细胞、支架和生物制造方法来修复受损的心脏组织。新技术使得利用人工智能设计心脏贴片和4D生物打印来制造对时间有反应的生物材料成为可能。这些程序比传统程序向前迈出了一大步，因为它们提供了更高的准确性、灵活性，并且有可能为每位患者量身定制治疗方法。本文综述了细胞来源、生物材料、生物打印平台以及免疫学、调控和转化等方面的最新进展。我们通过观察CTE的优点和缺点，展示了在临床环境中使用CTE的现实方法。创新生物材料促进心脏组织再生。3D生物打印彻底改变了心脏组织的制造。针对患者的干细胞疗法提供个性化的解决方案。人工智能和4D打印促进了组织设计和临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent Advances in Cardiac Tissue Engineering: Innovations and Future Directions

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Recent Advances in Cardiac Tissue Engineering: Innovations and Future Directions

Cardiac tissue engineering (CTE) is a rapidly evolving field that combines cells, scaffolds, and biofabrication methods to repair damaged heart tissue. New technologies have made it possible to utilize AI in designing cardiac patches and 4D bioprinting to create biomaterials that respond to time. These procedures are a big step forward from traditional ones since they offer more accuracy, flexibility, and the possibility of therapies that are tailored to each patient. This review talks about the latest developments in cellular sources, biomaterials, and bioprinting platforms, as well as immunological, regulatory, and translational issues. We show a realistic way forward for using CTE in clinical settings by looking at both its strengths and weaknesses.

Summary

Innovative biomaterials enhance cardiac tissue regeneration.
3D bioprinting revolutionizes cardiac tissue fabrication.
Patient-specific stem cell therapies offer personalized solutions.
AI and 4D printing advance tissue design and clinical applications.

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来源期刊

Biotechnology Journal Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

8.90

自引率

2.10%

发文量

123

审稿时长

1.5 months

期刊介绍： Biotechnology Journal (2019 Journal Citation Reports: 3.543) is fully comprehensive in its scope and publishes strictly peer-reviewed papers covering novel aspects and methods in all areas of biotechnology. Some issues are devoted to a special topic, providing the latest information on the most crucial areas of research and technological advances. In addition to these special issues, the journal welcomes unsolicited submissions for primary research articles, such as Research Articles, Rapid Communications and Biotech Methods. BTJ also welcomes proposals of Review Articles - please send in a brief outline of the article and the senior author''s CV to the editorial office. BTJ promotes a special emphasis on: Systems Biotechnology Synthetic Biology and Metabolic Engineering Nanobiotechnology and Biomaterials Tissue engineering, Regenerative Medicine and Stem cells Gene Editing, Gene therapy and Immunotherapy Omics technologies Industrial Biotechnology, Biopharmaceuticals and Biocatalysis Bioprocess engineering and Downstream processing Plant Biotechnology Biosafety, Biotech Ethics, Science Communication Methods and Advances.