吉兰-巴罗综合征结局的种族差异：一年分析

IF 2.3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of the National Medical Association Pub Date : 2025-09-01 DOI:10.1016/j.jnma.2025.08.068

Quinton D. Johnson BS, Emmanuel Y. Kerolle BS, Amara A. Chike BS, Jeff G. Palmer BS, Somtochi A. Edeh BS, Samrawit W. Zinabu MD, Miriam B. Michael MD

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引用次数: 0

摘要

格林-巴勒综合征（GBS）是一种急性自身免疫性神经病变，可导致瘫痪、肌肉无力、感觉缺陷和死亡。在医疗保健和疾病结局方面的种族差异是有目可睹的，但它们对GBS结局的影响尚不清楚。本研究调查了黑人/非裔美国人和白人/高加索患者合并症匹配的一年结果（麻痹、麻木、肌肉无力和死亡率）。方法采用倾向匹配的黑人/非裔美国人和白人/白种人诊断为GBS患者进行回顾性队列研究。匹配标准包括合并症，如糖尿病、肥胖、妊娠相关疾病、呼吸系统疾病和循环系统疾病。采用风险分析、Kaplan-Meier生存分析和t检验来评估种族间结局的差异。结果黑人和白人患者在麻痹（p = 0.163）、麻木（p = 0.849）、肌肉无力（p = 0.333）和死亡率（p = 0.694）方面差异无统计学意义。Kaplan-Meier生存分析也显示在任何结果的事件发生时间上没有显著差异。结论本研究表明，在调整了主要合并症后，种族背景对GBS的一年预后没有显著影响。这些发现突出了公平医疗和早期干预的重要性。未来的研究应探讨医疗保健的可及性、治疗差异和长期功能恢复，以进一步了解潜在的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Racial Differences in Guillain-Barré Syndrome Outcomes: One-Year Analysis

Introduction

Guillain-Barré Syndrome (GBS) is an acute autoimmune neuropathy that can lead to paralysis, muscle weakness, sensory deficits, and mortality. Racial disparities in healthcare access and disease outcomes are well-documented, but their impact on GBS outcomes remains unclear. This study examines one-year outcomes (paralysis, numbness, muscle weakness, and mortality) in Black/African American and White/Caucasian patients matched for comorbidities.

Methods

A retrospective cohort study was conducted using propensity-matched Black/African American and White/Caucasian patients diagnosed with GBS. Matching criteria included comorbid conditions such as diabetes, obesity, pregnancy-related conditions, respiratory diseases, and circulatory diseases. Risk analysis, Kaplan-Meier survival analysis, and t-tests were performed to assess differences in outcomes between racial groups.

Results

No statistically significant differences were found between Black and White patients for paralysis (p = 0.163), numbness (p = 0.849), muscle weakness (p = 0.333), or mortality (p = 0.694). Kaplan-Meier survival analysis also showed no significant difference in time-to- event for any outcome.

Conclusion

This study suggests that, after adjusting for key comorbidities, racial background does not significantly influence one-year outcomes in GBS. These findings highlight the importance of equitable medical care and early intervention. Future research should explore healthcare access, treatment differences, and long-term functional recovery to further understand potential disparities.

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来源期刊

Journal of the National Medical Association 医学-医学：内科

CiteScore

4.80

自引率

3.00%

发文量

139

审稿时长

98 days

期刊介绍： Journal of the National Medical Association, the official journal of the National Medical Association, is a peer-reviewed publication whose purpose is to address medical care disparities of persons of African descent. The Journal of the National Medical Association is focused on specialized clinical research activities related to the health problems of African Americans and other minority groups. Special emphasis is placed on the application of medical science to improve the healthcare of underserved populations both in the United States and abroad. The Journal has the following objectives: (1) to expand the base of original peer-reviewed literature and the quality of that research on the topic of minority health; (2) to provide greater dissemination of this research; (3) to offer appropriate and timely recognition of the significant contributions of physicians who serve these populations; and (4) to promote engagement by member and non-member physicians in the overall goals and objectives of the National Medical Association.