HJURP在癌症中的多重作用：对肿瘤发生和治疗靶向的影响

IF 2.4 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2025-09-01 DOI:10.1016/j.gene.2025.149751

Nikita Taneja , Akansha Chauhan , Vandana Mehra , Sandhya Singh

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引用次数: 0

摘要

假日连接识别蛋白（HJURP）通过其在CENP-A沉积中的作用对着丝粒完整性和染色体稳定性至关重要。新的研究表明，HJURP还参与了癌症生物学的各个方面，包括肿瘤的发生、进展和转移。目的全面回顾HJURP在癌症中的分子和临床意义，重点关注其在基因组维持、癌症特征以及作为预后生物标志物和治疗靶点的潜力方面的作用。方法对已发表的研究进行系统回顾。此外，从cBioPortal检索HJURP的突变数据，并使用R进行分析，生成棒棒糖图，确定多种癌症类型的突变热点和突变类型。蛋白质相互作用网络和最近的治疗研究也进行了评价。结果shjurp在癌症中表现出上下文依赖的功能，既可以作为癌基因，也可以作为肿瘤抑制因子。它涉及癌症的特征，如细胞周期失调、DNA修复缺陷、细胞凋亡逃避、上皮-间质转化、代谢改变和免疫逃避。生物信息学分析揭示了可能影响其功能域的反复突变。结论hjurp是肿瘤生物学中的关键调控因子，具有诊断和治疗潜力。靶向HJURP可能为个性化癌症治疗和改善患者预后提供新的策略。

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The multifaceted role of HJURP in cancer: Implications for tumorigenesis and therapeutic targeting

Background

Holliday Junction Recognition Protein (HJURP) is essential for centromere integrity and chromosomal stability through its role in CENP-A deposition. Emerging studies suggest that HJURP also contributes to various aspects of cancer biology, including tumor initiation, progression, and metastasis.

Objective

To comprehensively review the molecular and clinical relevance of HJURP in cancer, with a focus on its role in genomic maintenance, cancer hallmarks, and its potential as a prognostic biomarker and therapeutic target.

Methods

A systematic review of published studies was conducted. In addition, mutation data for HJURP were retrieved from cBioPortal and analyzed using R to generate lollipop plots, identifying mutational hotspots and mutation types across multiple cancer types. Protein interaction networks and recent therapeutic research were also evaluated.

Results

HJURP exhibits context-dependent functions in cancer, acting either as an oncogene or tumor suppressor. It is implicated in cancer hallmarks such as cell cycle dysregulation, DNA repair defects, apoptosis evasion, epithelial–mesenchymal transition, metabolic alterations, and immune evasion. The bioinformatics analysis revealed recurrent mutations that may affect its functional domains.

Conclusion

HJURP is a key regulator in cancer biology with diagnostic and therapeutic potential. Targeting HJURP may provide novel strategies for personalized cancer treatment and improved patient outcomes.

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.