Marco Vincenzo Lenti, Alice Silvia Brera, Giacomo Broglio, Giampiera Bertolino, Antonio Di Sabatino, Catherine Klersy, Gino Roberto Corazza
{"title":"住院和非住院炎症性肠病患者共病相关因素:一项单中心初步研究","authors":"Marco Vincenzo Lenti, Alice Silvia Brera, Giacomo Broglio, Giampiera Bertolino, Antonio Di Sabatino, Catherine Klersy, Gino Roberto Corazza","doi":"10.1177/26335565251365040","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) may be burdened by other comorbid conditions. We herein sought to assess comorbidity in hospitalized and non-hospitalized IBD patients.</p><p><strong>Methods: </strong>This was part of the San MAtteo Complexity (SMAC) study (2017-2019). Data of hospitalized IBD patients were compared to gender- and age-matched IBD outpatients in a 2:1 fashion. The association of comorbidity in relation to hospitalization and clinical and socioeconomic factors was assessed.</p><p><strong>Results: </strong>We included 104 patients, 27 hospitalized (median age 49 years, IQR 32-70) and 77 outpatients (median age 54 years, IQR 37-68). Comorbidity was reported in 63/104 patients (60.6%), of whom 45 (58.5%) non-hospitalized and 18 (66.6%) hospitalized. Patients with comorbidity were older (median 60 years, IQR 44-61 vs median 40 years, IQR 28-50 vs; p<0.001), had a higher Cumulative Illness Rating Scale severity index (median 1.85, IQR 1.5-2.5 vs median 1.31, IQR 1.2-2.5; p=0.002), were more commonly female (37, 60.7% vs 14, 35.0%; p=0.01), frailer (14, 22.2% vs 1, 2.4%; p=0.004), and had a lower educational level (13, 20.6% vs 2, 4.9%; p=0.04). In a bivariable analysis, factors associated to comorbidity were age >65 years (OR 5.30, 95% CI 1.81-15.55; p=0.002), female sex (OR 2.92, 95% CI 1-27-6.71; p=0.012), income <1000€ (OR 3.04, 95% CI 1.09-8.44; p=0.033), schooling <8 years (OR 5.09, 95% CI 1.08-23.96; p=0.039), frailty (OR 12.56, 95% CI 1.48-106.45; p=0.020), and polypharmacy (OR 10.41, 95% CI 1.85-59.38; p=0.008).</p><p><strong>Conclusion: </strong>A high prevalence of comorbidity was found in IBD, possibly related to low socioeconomic status and poor educational level.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"15 ","pages":"26335565251365040"},"PeriodicalIF":3.0000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371177/pdf/","citationCount":"0","resultStr":"{\"title\":\"Factors associated with comorbidity in hospitalized and non-hospitalized inflammatory bowel disease patients: A single-center, preliminary study.\",\"authors\":\"Marco Vincenzo Lenti, Alice Silvia Brera, Giacomo Broglio, Giampiera Bertolino, Antonio Di Sabatino, Catherine Klersy, Gino Roberto Corazza\",\"doi\":\"10.1177/26335565251365040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) may be burdened by other comorbid conditions. We herein sought to assess comorbidity in hospitalized and non-hospitalized IBD patients.</p><p><strong>Methods: </strong>This was part of the San MAtteo Complexity (SMAC) study (2017-2019). Data of hospitalized IBD patients were compared to gender- and age-matched IBD outpatients in a 2:1 fashion. The association of comorbidity in relation to hospitalization and clinical and socioeconomic factors was assessed.</p><p><strong>Results: </strong>We included 104 patients, 27 hospitalized (median age 49 years, IQR 32-70) and 77 outpatients (median age 54 years, IQR 37-68). Comorbidity was reported in 63/104 patients (60.6%), of whom 45 (58.5%) non-hospitalized and 18 (66.6%) hospitalized. Patients with comorbidity were older (median 60 years, IQR 44-61 vs median 40 years, IQR 28-50 vs; p<0.001), had a higher Cumulative Illness Rating Scale severity index (median 1.85, IQR 1.5-2.5 vs median 1.31, IQR 1.2-2.5; p=0.002), were more commonly female (37, 60.7% vs 14, 35.0%; p=0.01), frailer (14, 22.2% vs 1, 2.4%; p=0.004), and had a lower educational level (13, 20.6% vs 2, 4.9%; p=0.04). In a bivariable analysis, factors associated to comorbidity were age >65 years (OR 5.30, 95% CI 1.81-15.55; p=0.002), female sex (OR 2.92, 95% CI 1-27-6.71; p=0.012), income <1000€ (OR 3.04, 95% CI 1.09-8.44; p=0.033), schooling <8 years (OR 5.09, 95% CI 1.08-23.96; p=0.039), frailty (OR 12.56, 95% CI 1.48-106.45; p=0.020), and polypharmacy (OR 10.41, 95% CI 1.85-59.38; p=0.008).</p><p><strong>Conclusion: </strong>A high prevalence of comorbidity was found in IBD, possibly related to low socioeconomic status and poor educational level.</p>\",\"PeriodicalId\":73843,\"journal\":{\"name\":\"Journal of multimorbidity and comorbidity\",\"volume\":\"15 \",\"pages\":\"26335565251365040\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371177/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of multimorbidity and comorbidity\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/26335565251365040\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of multimorbidity and comorbidity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/26335565251365040","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:炎症性肠病(IBD)可能由其他合并症引起。我们在此试图评估住院和非住院IBD患者的合并症。方法:这是圣马特奥复杂性(SMAC)研究(2017-2019)的一部分。将住院IBD患者的数据与性别和年龄匹配的IBD门诊患者以2:1的比例进行比较。评估合并症与住院、临床和社会经济因素的关系。结果:纳入104例患者,住院27例(中位年龄49岁,IQR 32-70),门诊77例(中位年龄54岁,IQR 37-68)。共病63/104例(60.6%),其中未住院45例(58.5%),住院18例(66.6%)。合并症患者年龄较大(中位60岁,IQR 44-61 vs中位40岁,IQR 28-50 vs; p65岁(OR 5.30, 95% CI 1.81-15.55; p=0.002)、女性(OR 2.92, 95% CI 1-27-6.71; p=0.012)、收入。结论:IBD患者合并症发生率高,可能与社会经济地位低、受教育程度低有关。
Factors associated with comorbidity in hospitalized and non-hospitalized inflammatory bowel disease patients: A single-center, preliminary study.
Background: Inflammatory bowel disease (IBD) may be burdened by other comorbid conditions. We herein sought to assess comorbidity in hospitalized and non-hospitalized IBD patients.
Methods: This was part of the San MAtteo Complexity (SMAC) study (2017-2019). Data of hospitalized IBD patients were compared to gender- and age-matched IBD outpatients in a 2:1 fashion. The association of comorbidity in relation to hospitalization and clinical and socioeconomic factors was assessed.
Results: We included 104 patients, 27 hospitalized (median age 49 years, IQR 32-70) and 77 outpatients (median age 54 years, IQR 37-68). Comorbidity was reported in 63/104 patients (60.6%), of whom 45 (58.5%) non-hospitalized and 18 (66.6%) hospitalized. Patients with comorbidity were older (median 60 years, IQR 44-61 vs median 40 years, IQR 28-50 vs; p<0.001), had a higher Cumulative Illness Rating Scale severity index (median 1.85, IQR 1.5-2.5 vs median 1.31, IQR 1.2-2.5; p=0.002), were more commonly female (37, 60.7% vs 14, 35.0%; p=0.01), frailer (14, 22.2% vs 1, 2.4%; p=0.004), and had a lower educational level (13, 20.6% vs 2, 4.9%; p=0.04). In a bivariable analysis, factors associated to comorbidity were age >65 years (OR 5.30, 95% CI 1.81-15.55; p=0.002), female sex (OR 2.92, 95% CI 1-27-6.71; p=0.012), income <1000€ (OR 3.04, 95% CI 1.09-8.44; p=0.033), schooling <8 years (OR 5.09, 95% CI 1.08-23.96; p=0.039), frailty (OR 12.56, 95% CI 1.48-106.45; p=0.020), and polypharmacy (OR 10.41, 95% CI 1.85-59.38; p=0.008).
Conclusion: A high prevalence of comorbidity was found in IBD, possibly related to low socioeconomic status and poor educational level.