Dmitrii N Andreev, Alsu R Khurmatullina, Igor V Maev, Dmitry S Bordin, Sayar R Abdulkhakov, Yury A Kucheryavyy, Petr A Beliy, Filipp S Sokolov
{"title":"俄罗斯成人幽门螺杆菌感染率：系统回顾和荟萃分析。","authors":"Dmitrii N Andreev, Alsu R Khurmatullina, Igor V Maev, Dmitry S Bordin, Sayar R Abdulkhakov, Yury A Kucheryavyy, Petr A Beliy, Filipp S Sokolov","doi":"10.3390/epidemiologia6030047","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objective:</b> The objective of this study is to assess the dynamics of <i>Helicobacter pylori</i> infection prevalence among adults in Russia. <b>Methods:</b> A systematic search was conducted in MEDLINE/PubMed, EMBASE, Cochrane, RSCI, and Google Scholar for studies published between 1985 and 27 February 2025, following PRISMA guidelines. The meta-analysis was registered in PROSPERO (CRD420251011643). <b>Results:</b> Twenty studies were included (n = 117,841; weighted mean age: 43.71 ± 16.23 years), all using validated diagnostic methods. The pooled prevalence from 1994 to 2024 was 62.847% (95% CI: 55.101-70.274), including 45.143% (95% CI: 41.390-48.923) by the <sup>13</sup>C-urea breath test and 75.806% (95% CI: 64.213-85.742) by serology. Prevalence declined over time: it was 79.334% before 2005, 74.074% in 2006-2011, and 66.319% in 2012-2017, and it has been 42.949% since 2018. Meta-regression confirmed a significant decrease (coefficient: -3.773% per year, <i>p</i> < 0.001). <b>Conclusions:</b> A significant decline in the prevalence of <i>H. pylori</i> has been observed, however, it remains relatively high and requires continued efforts aimed at diagnosis and eradication.</p>","PeriodicalId":72944,"journal":{"name":"Epidemiolgia (Basel, Switzerland)","volume":"6 3","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372033/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Prevalence of <i>Helicobacter pylori</i> Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis.\",\"authors\":\"Dmitrii N Andreev, Alsu R Khurmatullina, Igor V Maev, Dmitry S Bordin, Sayar R Abdulkhakov, Yury A Kucheryavyy, Petr A Beliy, Filipp S Sokolov\",\"doi\":\"10.3390/epidemiologia6030047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objective:</b> The objective of this study is to assess the dynamics of <i>Helicobacter pylori</i> infection prevalence among adults in Russia. <b>Methods:</b> A systematic search was conducted in MEDLINE/PubMed, EMBASE, Cochrane, RSCI, and Google Scholar for studies published between 1985 and 27 February 2025, following PRISMA guidelines. The meta-analysis was registered in PROSPERO (CRD420251011643). <b>Results:</b> Twenty studies were included (n = 117,841; weighted mean age: 43.71 ± 16.23 years), all using validated diagnostic methods. The pooled prevalence from 1994 to 2024 was 62.847% (95% CI: 55.101-70.274), including 45.143% (95% CI: 41.390-48.923) by the <sup>13</sup>C-urea breath test and 75.806% (95% CI: 64.213-85.742) by serology. Prevalence declined over time: it was 79.334% before 2005, 74.074% in 2006-2011, and 66.319% in 2012-2017, and it has been 42.949% since 2018. Meta-regression confirmed a significant decrease (coefficient: -3.773% per year, <i>p</i> < 0.001). <b>Conclusions:</b> A significant decline in the prevalence of <i>H. pylori</i> has been observed, however, it remains relatively high and requires continued efforts aimed at diagnosis and eradication.</p>\",\"PeriodicalId\":72944,\"journal\":{\"name\":\"Epidemiolgia (Basel, Switzerland)\",\"volume\":\"6 3\",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372033/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemiolgia (Basel, Switzerland)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/epidemiologia6030047\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiolgia (Basel, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/epidemiologia6030047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis.
Objective: The objective of this study is to assess the dynamics of Helicobacter pylori infection prevalence among adults in Russia. Methods: A systematic search was conducted in MEDLINE/PubMed, EMBASE, Cochrane, RSCI, and Google Scholar for studies published between 1985 and 27 February 2025, following PRISMA guidelines. The meta-analysis was registered in PROSPERO (CRD420251011643). Results: Twenty studies were included (n = 117,841; weighted mean age: 43.71 ± 16.23 years), all using validated diagnostic methods. The pooled prevalence from 1994 to 2024 was 62.847% (95% CI: 55.101-70.274), including 45.143% (95% CI: 41.390-48.923) by the 13C-urea breath test and 75.806% (95% CI: 64.213-85.742) by serology. Prevalence declined over time: it was 79.334% before 2005, 74.074% in 2006-2011, and 66.319% in 2012-2017, and it has been 42.949% since 2018. Meta-regression confirmed a significant decrease (coefficient: -3.773% per year, p < 0.001). Conclusions: A significant decline in the prevalence of H. pylori has been observed, however, it remains relatively high and requires continued efforts aimed at diagnosis and eradication.
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