产前环境暴露与大脑发育:对狒狒和其他非人类灵长类动物的研究。

Advances in drug and alcohol research Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI:10.3389/adar.2025.14858
Igor Y Iskusnykh, Shiwani Thapa, Victor V Chizhikov, Anna N Bukiya
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引用次数: 0

摘要

在怀孕期间,胎儿大脑发育迅速,对环境影响高度敏感。了解胎儿大脑发育的复杂过程对于促进母胎健康和减轻与发育性大脑疾病相关的风险至关重要。非人灵长类动物(NHP)动物模型为研究怀孕期间的大脑发育提供了一个独特的、高度可翻译的平台,因为这些动物在解剖、生理和行为上与人类非常相似。我们的综述探讨了NHP模型在阐明产前脑成熟的关键里程碑以及控制典型和非典型发育的机制中的应用。我们进一步研究了环境损害对胎儿大脑发育的影响,包括空气污染、感染、电离辐射和接触有毒物质,并强调了这些因素可以破坏大脑发育和神经回路,导致长期认知和行为缺陷的方式。最近的研究表明,狒狒(Papio hamadryas)动物模型为研究环境对妊娠的不利影响提供了一个富有成效但尚未充分利用的转化模型。最后,我们回顾了药物滥用对胎儿大脑发育的影响,强调了通过临床和实验室研究确定的潜在生物学机制。综合方法提供了对发育中的神经系统脆弱性的全面了解,为治疗和预防神经发育障碍提供了新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates.

Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates.

Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates.

Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates.

During pregnancy, the fetal brain undergoes rapid development and is highly sensitive to environmental influences. Understanding the intricate processes that underlie fetal brain development will be critical for advancing maternal-fetal health and mitigating the risks associated with developmental brain disorders. Nonhuman primate (NHP) animal models provide a unique and highly translational platform for studying brain development during pregnancy due to the close anatomical, physiological, and behavioral resemblance of these animals to humans. Our review explores the use of NHP models in elucidating key milestones of prenatal brain maturation and the mechanisms that govern typical and atypical development. We further examine the impact of environmental insults on fetal brain development, including air pollution, infection, ionizing radiation, and exposure to toxicants, and highlight the ways in which these factors can disrupt brain development and neural circuitry, leading to long-term cognitive and behavioral deficits. Recent studies demonstrate that the baboon (Papio hamadryas) animal model provides a fruitful yet underused translational model for research related to environmental adverse effects on pregnancy. Lastly, we review the effects of drugs of abuse on the developing fetal brain, highlighting the underlying biological mechanisms identified through clinical and laboratory studies. A combined approach offers a comprehensive understanding of the vulnerabilities of the developing nervous system, informing new strategies for the treatment and prevention of neurodevelopmental disorders.

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