心血管疾病的重量:解决与肥胖相关的全球心血管危机。

IF 3.1 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Global Heart Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI:10.5334/gh.1451
Francisco Lopez-Jimenez, Mariachiara Di Cesare, Jaynaide Powis, Shreya Shrikhande, Marvellous Adeoye, Elisa Codato, Bin Zhou, Honor Bixby, Natalie Evans, Kyla Lara-Breitinger, Mariana Arellano Rodriguez, Lisa Hadeed, Simon Barquera, Sean Taylor, Pablo Perel, Daniel Pineiro, Jagat Narula, Fausto Pinto
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引用次数: 0

摘要

肥胖是一种日益增长的全球流行病,对心血管疾病(CVD)具有重要影响。它是导致心血管疾病的多种途径的独立风险因素和驱动因素。在这里,我们研究肥胖对心血管疾病的影响,并提出可行的策略。数据来自非传染性疾病风险因素协作(NCD- risc)、全球疾病负担(GBD)调查和区域健康调查数据库。我们研究了高体重指数(BMI)导致的肥胖患病率和心血管疾病死亡率的趋势,并按性别、地理位置、社会经济地位和城乡居住情况进行了分类。还审查了来自国家政策倡议和临床管理指南的证据。截至2022年,全球有超过10亿人患有肥胖症。自1990年以来,年龄标准化的肥胖患病率在女性中翻了一番(从8.8%到18.5%),在男性中翻了三倍(从4.8%到14%)。在全球范围内,由高BMI (25 kg/m2或以上)导致的年度心血管疾病死亡人数在1990年至2021年期间增加了一倍以上,在2021年达到190万人。到2060年,将全球肥胖减少到2019年的水平,估计每年可节省2.2万亿美元。近年来已经取得了积极的进展,一些全球、国家和地方倡议的实施显示出解决肥胖和心血管疾病的希望,此外还有可能改变游戏规则的医疗干预措施的出现,如胰高血糖素样肽-1受体激动剂(GLP-1RAs)。然而,为了解决肥胖和相关的心血管疾病,需要采取综合的临床和公共卫生干预措施,考虑肥胖的多重决定因素。我们建议实施循证的、具有成本效益的公共卫生措施,并将针对肥胖的建议纳入心血管指南。解决与肥胖相关的全球心血管危机需要决策者、医疗保健系统和全球卫生组织的协调努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Weight of Cardiovascular Diseases: Addressing the Global Cardiovascular Crisis Associated with Obesity.

Obesity is a growing global epidemic with significant implications for cardiovascular diseases (CVD). It couples as an independent risk factor and driver for multiple pathways leading to CVDs. Here we examine obesity's impact on CVD and propose actionable strategies. Data from the NCD Risk Factor Collaboration (NCD-RisC), Global Burden of Disease (GBD) survey, and regional health surveys databases were used. We examined trends in obesity prevalence and CVD mortality attributable to high body mass index (BMI), disaggregated by sex, geography, socioeconomic status, and urban-rural residence. Evidence from national policy initiatives and clinical management guidelines was also reviewed. As of 2022, over 1 billion people globally were living with obesity. Since 1990 the age-standardised obesity prevalence has doubled among women (from 8.8% to 18.5%) and tripled among men (from 4.8% to 14%). Globally, the number of annual CVD deaths attributable to high BMI (25 kg/m2 or over) more than doubled between 1990 and 2021, reaching 1.9 million in 2021. Reducing global obesity to 2019 levels could save an estimated US$2.2 trillion annually by 2060. Positive steps have been made in recent years, with the implementation of several global, national and local initiatives that show promise in tackling obesity and CVDs, in addition to the emergence of potentially game-changing medical interventions, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs). Yet, to tackle obesity and associated CVD, there is a need for a holistic approach across clinical and public health interventions that accounts for the multiple determinants of obesity. We recommend the implementation of evidence-based, cost-effective public health measures, and the incorporation of obesity-specific recommendations into cardiovascular guidelines. Addressing the global cardiovascular crisis linked to obesity will require coordinated efforts from policymakers, healthcare systems, and global health organisations.

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来源期刊
Global Heart
Global Heart Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.70
自引率
5.40%
发文量
77
审稿时长
5 weeks
期刊介绍: Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.
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