WHF单丸联合治疗路线图。

IF 3.1 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Global Heart Pub Date : 2025-08-29 eCollection Date: 2025-01-01 DOI:10.5334/gh.1457
Enrico G Ferro, Gautam Satheesh, José Castellano, Albertino Damasceno, Okeoma Erojikwe, Mark Huffman, Vilma Irazola, Philip Joseph, Fernando Lanas, Elijah Ogola, Pedro Ordunez, Pablo Perel, Daniel Pineiro, Izabela Uchmanowicz, Orly Vardeny, Ruth Webster, Habib Gamra, Thomas Gaziano, Adrianna Murphy
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引用次数: 0

摘要

心血管疾病是全球主要的死亡原因,坚持治疗是有效预防和控制的主要障碍。单丸联合,也称为固定剂量联合,通过将多种药物合并到一粒药丸中,简化了治疗,提高了依从性并降低了心血管风险。这份世界心脏联合会路线图综合了最新的临床证据,并确定了SPC实施的主要障碍,包括有限的生产、可负担性、监管复杂性和指南不一致。根据全球专家的投入和卫生系统分析,该路线图概述了切实可行的、针对具体情况的解决方案,以改善特别是在低收入和中等收入国家的特别保健服务的获取、扩大和纳入国家战略。它是政策制定者、临床医生和倡导者推动在将心血管预防工作与循证、以人为本的护理相结合方面取得进展的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

WHF Roadmap on Single Pill Combination Therapies.

WHF Roadmap on Single Pill Combination Therapies.

Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially in low- and middle-income countries. It serves as a tool for policymakers, clinicians, and advocates to drive progress in aligning cardiovascular prevention efforts with evidence-based, people-centred care.

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来源期刊
Global Heart
Global Heart Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.70
自引率
5.40%
发文量
77
审稿时长
5 weeks
期刊介绍: Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.
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