João Vital Arthur Maradona Oliveira Dias, Vitor Ricardo Alves Pereira de Moraes, Matheus Trindade Bruxelas de Freitas, Matheus Manolo Arouca, Guilherme Pereira Ocampos, Olavo Pires de Camargo, Márcia Uchoa de Rezende
{"title":"膝神经消融治疗膝骨关节炎：一项随机前瞻性研究。","authors":"João Vital Arthur Maradona Oliveira Dias, Vitor Ricardo Alves Pereira de Moraes, Matheus Trindade Bruxelas de Freitas, Matheus Manolo Arouca, Guilherme Pereira Ocampos, Olavo Pires de Camargo, Márcia Uchoa de Rezende","doi":"10.1590/1413-785220253303e289218","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To document the effects of genicular nerve ablation in patients with severe knee osteoarthritis (OAJ) at 1 and 3 months.</p><p><strong>Methods: </strong>Prospective, randomized, and controlled trial with 35 patients with grade IV knee osteoarthritis according to Kelgren & Lawrence, undergoing genicular nerve ablation with pulsed radiofrequency (PRF) or phenol. Outcomes were assessed at baseline, 1 month, and 3 months using the Numeric Rating Scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), the 30-Second Chair Stand Test (TSL30), and the Timed Up and Go (TUG) test.</p><p><strong>Results: </strong>The groups were similar at baseline. Both groups improved similarly up to 3 months (p<0.001). NRS decreased by an average of 30% from baseline to all subsequent assessments (p<0.05). TUG decreased between baseline and one month post-procedure (p=0.001), while TSL30 increased from baseline to one and three months (p<0.05). The average behavior of patients was equal between groups over the evaluations for all scores (p Interaction > 0.05). None of the scores differed between groups, regardless of the evaluation period (p Group > 0.05).</p><p><strong>Conclusions: </strong>Genicular nerve ablation in patients with severe OAJ can provide lasting improvements in pain, function, and quality of life. Both methods, phenol and radiofrequency, are effective. <b><i>Level of Evidence I; Controlled Randomized Clinical Trial</i></b> .</p>","PeriodicalId":55563,"journal":{"name":"Acta Ortopedica Brasileira","volume":"33 3","pages":"e289218"},"PeriodicalIF":0.6000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364514/pdf/","citationCount":"0","resultStr":"{\"title\":\"GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY.\",\"authors\":\"João Vital Arthur Maradona Oliveira Dias, Vitor Ricardo Alves Pereira de Moraes, Matheus Trindade Bruxelas de Freitas, Matheus Manolo Arouca, Guilherme Pereira Ocampos, Olavo Pires de Camargo, Márcia Uchoa de Rezende\",\"doi\":\"10.1590/1413-785220253303e289218\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To document the effects of genicular nerve ablation in patients with severe knee osteoarthritis (OAJ) at 1 and 3 months.</p><p><strong>Methods: </strong>Prospective, randomized, and controlled trial with 35 patients with grade IV knee osteoarthritis according to Kelgren & Lawrence, undergoing genicular nerve ablation with pulsed radiofrequency (PRF) or phenol. Outcomes were assessed at baseline, 1 month, and 3 months using the Numeric Rating Scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), the 30-Second Chair Stand Test (TSL30), and the Timed Up and Go (TUG) test.</p><p><strong>Results: </strong>The groups were similar at baseline. Both groups improved similarly up to 3 months (p<0.001). NRS decreased by an average of 30% from baseline to all subsequent assessments (p<0.05). TUG decreased between baseline and one month post-procedure (p=0.001), while TSL30 increased from baseline to one and three months (p<0.05). The average behavior of patients was equal between groups over the evaluations for all scores (p Interaction > 0.05). None of the scores differed between groups, regardless of the evaluation period (p Group > 0.05).</p><p><strong>Conclusions: </strong>Genicular nerve ablation in patients with severe OAJ can provide lasting improvements in pain, function, and quality of life. Both methods, phenol and radiofrequency, are effective. <b><i>Level of Evidence I; Controlled Randomized Clinical Trial</i></b> .</p>\",\"PeriodicalId\":55563,\"journal\":{\"name\":\"Acta Ortopedica Brasileira\",\"volume\":\"33 3\",\"pages\":\"e289218\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364514/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Ortopedica Brasileira\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1590/1413-785220253303e289218\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Ortopedica Brasileira","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/1413-785220253303e289218","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY.
Objective: To document the effects of genicular nerve ablation in patients with severe knee osteoarthritis (OAJ) at 1 and 3 months.
Methods: Prospective, randomized, and controlled trial with 35 patients with grade IV knee osteoarthritis according to Kelgren & Lawrence, undergoing genicular nerve ablation with pulsed radiofrequency (PRF) or phenol. Outcomes were assessed at baseline, 1 month, and 3 months using the Numeric Rating Scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), the 30-Second Chair Stand Test (TSL30), and the Timed Up and Go (TUG) test.
Results: The groups were similar at baseline. Both groups improved similarly up to 3 months (p<0.001). NRS decreased by an average of 30% from baseline to all subsequent assessments (p<0.05). TUG decreased between baseline and one month post-procedure (p=0.001), while TSL30 increased from baseline to one and three months (p<0.05). The average behavior of patients was equal between groups over the evaluations for all scores (p Interaction > 0.05). None of the scores differed between groups, regardless of the evaluation period (p Group > 0.05).
Conclusions: Genicular nerve ablation in patients with severe OAJ can provide lasting improvements in pain, function, and quality of life. Both methods, phenol and radiofrequency, are effective. Level of Evidence I; Controlled Randomized Clinical Trial .
期刊介绍：
A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.
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