解开德国荷斯坦奶牛的双胞胎:表型关联,遗传分析和潜在的潜在基因和激素。

IF 1.9 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Laura Hüneke, Hatem Alkhoder, Dierck Segelke, Georg Thaller, Christin Schmidtmann
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引用次数: 0

摘要

奶牛的双胞胎是罕见的,但对动物福利构成重大挑战,因为奶牛和小牛的健康都会受到影响。这会造成经济损失,这促使育种者对双胞胎进行选择,并确定相关的风险因素。本研究使用大型种群数据集研究了德国荷斯坦牛产奶量、生育性状和双胞胎之间的表型关系。估计GEBV与双胞胎出生、产奶量和生育性状的相关性。为了更详细地探索遗传背景,我们对产犊数1-3进行了全基因组关联研究(GWAS)。双胞胎出生率与产奶量表现出强烈的表型关联,与成功授精的时间表现出适度的表型关联。GEBV与产奶量的相关性为0.04,与育性性状的相关性为-0.10 ~ 0.01。GWAS发现BTA11上有两个潜在的候选基因:LHCGR和FSHR,它们编码LH和FSH的受体,这两种激素对发情至关重要。与第一次产犊相比,在2号和3号产犊中发现了BTA5和BTA25的显著相关区域。这项研究证明了基因型和环境之间的相互作用,结论是双胞胎出生的遗传易感性,加上有利的内分泌状态(环境),增加了双胞胎出生的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unravelling Twin Births in German Holstein Cows: Phenotypic Associations, Genetic Analysis and Potential Underlying Genes and Hormones.

Twin births in dairy cattle are rare but present significant challenges for animal welfare, as both the health of the cow and the calves are affected. This causes economic losses, which prompts breeders to select against twin births and identify associated risk factors. This study examines the phenotypic relationship between milk yield, fertility traits and twin births in German Holstein cattle using a large, population-wide dataset. GEBV correlations for twin births, milk production and fertility traits were estimated. Genome-wide association studies (GWAS) were conducted for calving numbers 1-3 in order to explore the genetic background in more detail. The twin birth rate showed a strong phenotypic association with milk production and a moderate phenotypic association with the timing of successful insemination. However, GEBV correlations were low: 0.04 with milk yield and -0.10 to 0.01 with fertility traits. GWAS revealed two potential candidate genes on BTA11: LHCGR and FSHR, which encode receptors for LH and FSH, two hormones crucial to estrus. In contrast to the first calving, significantly associated regions on BTA5 and BTA25 were found in calving numbers 2 and 3. This study demonstrates the interaction between genotype and environment, concluding that a genetic predisposition for twin births, in combination with a favourable endocrine state (environment), increases the likelihood of twin births.

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来源期刊
Journal of Animal Breeding and Genetics
Journal of Animal Breeding and Genetics 农林科学-奶制品与动物科学
CiteScore
5.20
自引率
3.80%
发文量
58
审稿时长
12-24 weeks
期刊介绍: The Journal of Animal Breeding and Genetics publishes original articles by international scientists on genomic selection, and any other topic related to breeding programmes, selection, quantitative genetic, genomics, diversity and evolution of domestic animals. Researchers, teachers, and the animal breeding industry will find the reports of interest. Book reviews appear in many issues.
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