肿瘤发生中乳酸化和RNA修饰之间的串扰：机制和治疗意义。

IF 11.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarker Research Pub Date : 2025-08-26 DOI:10.1186/s40364-025-00824-9

Shantong Liu, Qianquan Ma, Chong Zeng, Haoyu Li, Jun Su, Zhihao Song, Ruyu Yan, Zijin Zhao, Songhai Tian, Wei Huang

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引用次数: 0

摘要

复杂的串扰发生在蛋白质和核酸修饰之间，乳酸化是一种新兴的翻译后修饰（PTM），与肿瘤进展有关。然而，介导乳酸化和RNA修饰之间的串扰及其在疾病发病机制中的作用的机制在很大程度上仍未得到解决。在这篇综述中，我们总结了目前在乳酸化和RNA修饰之间的调节相互作用的进展，探讨了它们在癌症生物学中的功能意义，并讨论了针对这些修饰单独或联合的治疗潜力。这项工作旨在全面概述它们在癌症中的机制参与，并为精确靶向治疗的新策略提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications.

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Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications.

Complex crosstalk occurs between protein and nucleic acid modifications, with lactylation, an emerging post-translational modification (PTM), being implicated in tumor progression. However, the mechanisms mediating the crosstalk between lactylation and RNA modifications and their roles in disease pathogenesis remain largely unresolved. In this review, we summarize current advances in the regulatory interactions between lactylation and RNA modifications, explore their functional implications in cancer biology, and discuss the therapeutic potential of targeting these modifications individually or in combination. This work aims to provide a comprehensive overview of their mechanistic involvement in cancer and to inform novel strategies for precision-targeted therapy.

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来源期刊

Biomarker Research Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

15.80

自引率

1.80%

发文量

审稿时长

10 weeks

期刊介绍： Biomarker Research, an open-access, peer-reviewed journal, covers all aspects of biomarker investigation. It seeks to publish original discoveries, novel concepts, commentaries, and reviews across various biomedical disciplines. The field of biomarker research has progressed significantly with the rise of personalized medicine and individual health. Biomarkers play a crucial role in drug discovery and development, as well as in disease diagnosis, treatment, prognosis, and prevention, particularly in the genome era.