研究UBASH3B在癌症中的作用:结构相关性、生理功能和治疗可能性。

IF 12.8 1区 医学 Q1 ONCOLOGY
Sophie Werner, Cameron Westlake, Madeleine Ndahayo, Ishita Gupta, Daria A Gaykalova
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引用次数: 0

摘要

头颈部鳞状细胞癌(HNSCC)是全球第七大常见癌症,由于有效靶向治疗的可用性有限,它呈现出持续的临床挑战。最近的研究已经发现泛素相关和含SH3结构域的B (UBASH3B),一种酪氨酸磷酸酶,在HNSCC发病过程中是一个关键的致癌因素。UBASH3B表达升高与HNSCC患者的不良临床结果相关。在机制上,UBASH3B通过稳定表皮生长因子受体(EGFR)水平促进肿瘤进展,从而增强下游信号通路,促进癌细胞增殖、存活和治疗耐药性。在这篇综述中,我们全面概述了UBASH3B的结构特征和生理功能,并重点讨论了其在HNSCC肿瘤发生中的新作用。我们进一步探索靶向UBASH3B作为一种新的治疗靶点的潜力,强调其在重塑治疗范例方面的前景。阐明UBASH3B在HNSCC中的分子功能可能会发现新的脆弱性,并为开发针对其活性的新治疗策略铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Investigating the role of UBASH3B in cancer: structural relevance, physiological functions, and therapeutic possibilities.

Investigating the role of UBASH3B in cancer: structural relevance, physiological functions, and therapeutic possibilities.

Investigating the role of UBASH3B in cancer: structural relevance, physiological functions, and therapeutic possibilities.

Investigating the role of UBASH3B in cancer: structural relevance, physiological functions, and therapeutic possibilities.

Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer globally and presents a persistent clinical challenge due to the limited availability of effective targeted therapeutics. Recent studies have identified the ubiquitin-associated and SH3 domain-containing B (UBASH3B), a tyrosine phosphatase, as a key oncogenic player in HNSCC pathogenesis. Elevated UBASH3B expression correlates with poor clinical outcomes in HNSCC patients. Mechanistically, UBASH3B promotes tumor progression by stabilizing the epidermal growth factor receptor (EGFR) levels, thereby enhancing downstream signaling pathways that promote cancer cell proliferation, survival, and therapeutic resistance. In this review, we provide a comprehensive overview of the structural features and physiological functions of UBASH3B, along with a focused discussion on its emerging role in HNSCC tumorigenesis. We further explore the potential of targeting UBASH3B as a novel therapeutic target, underscoring its promise in reshaping treatment paradigms. Elucidating the molecular functions of UBASH3B in HNSCC may uncover new vulnerabilities and pave the way for the development of novel therapeutic strategies that target its activity.

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来源期刊
CiteScore
18.20
自引率
1.80%
发文量
333
审稿时长
1 months
期刊介绍: The Journal of Experimental & Clinical Cancer Research is an esteemed peer-reviewed publication that focuses on cancer research, encompassing everything from fundamental discoveries to practical applications. We welcome submissions that showcase groundbreaking advancements in the field of cancer research, especially those that bridge the gap between laboratory findings and clinical implementation. Our goal is to foster a deeper understanding of cancer, improve prevention and detection strategies, facilitate accurate diagnosis, and enhance treatment options. We are particularly interested in manuscripts that shed light on the mechanisms behind the development and progression of cancer, including metastasis. Additionally, we encourage submissions that explore molecular alterations or biomarkers that can help predict the efficacy of different treatments or identify drug resistance. Translational research related to targeted therapies, personalized medicine, tumor immunotherapy, and innovative approaches applicable to clinical investigations are also of great interest to us. We provide a platform for the dissemination of large-scale molecular characterizations of human tumors and encourage researchers to share their insights, discoveries, and methodologies with the wider scientific community. By publishing high-quality research articles, reviews, and commentaries, the Journal of Experimental & Clinical Cancer Research strives to contribute to the continuous improvement of cancer care and make a meaningful impact on patients' lives.
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