乳腺癌中异质癌症相关成纤维细胞亚群与免疫系统之间的串扰:关键参与者和有希望的治疗靶点。

IF 12.8 1区 医学 Q1 ONCOLOGY
Lu Liu, Weijun Wan, Yilin Chang, Luoquan Ao, Yan Xu, Xiang Xu
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引用次数: 0

摘要

乳腺癌的肿瘤微环境(TME)是一个复杂的生态系统,其中癌相关成纤维细胞(CAFs)作为最丰富的基质细胞类型,精心构建生态位,通过细胞外基质(ECM)重塑、生物活性因子的分泌以及与邻近细胞的相互作用等机制支持肿瘤生长。包括单细胞测序和空间转录组学在内的高分辨率技术揭示了CAF群体的高度异质性、功能多样性和空间分布。不同CAF亚群与免疫细胞之间的相互作用存在显著差异。它们通过与免疫系统的复杂串扰,共同建立免疫抑制网络,成为肿瘤免疫逃逸的核心驱动力。本文综述了乳腺癌微环境中异质CAF亚群的最新研究进展,探讨了不同CAF亚群与免疫细胞之间复杂的双向串扰如何协同塑造肿瘤免疫微环境(TIME),并总结了各种基于CAF的乳腺癌治疗策略。旨在为CAF异质性研究的临床翻译提供重要的理论基础和新的治疗视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Crosstalk between heterogeneous cancer-associated fibroblast subpopulations and the immune system in breast cancer: key players and promising therapeutic targets.

Crosstalk between heterogeneous cancer-associated fibroblast subpopulations and the immune system in breast cancer: key players and promising therapeutic targets.

Crosstalk between heterogeneous cancer-associated fibroblast subpopulations and the immune system in breast cancer: key players and promising therapeutic targets.

Crosstalk between heterogeneous cancer-associated fibroblast subpopulations and the immune system in breast cancer: key players and promising therapeutic targets.

The tumor microenvironment (TME) of breast cancer is a complex ecosystem, in which cancer-associated fibroblasts (CAFs), as the most abundant stromal cell type, meticulously construct an ecological niche that supports tumor growth through mechanisms including extracellular matrix (ECM) remodeling, secretion of bioactive factors, and interactions with neighboring cells. High-resolution technologies, including single-cell sequencing and spatial transcriptomics, have revealed the high heterogeneity, functional diversity, and spatial distribution within the CAF population. Significant differences exist in the interactions between distinct CAF subpopulations and immune cells. Through complex crosstalk with the immune system, they collaboratively establish an immunosuppressive network, becoming a core driving force for tumor immune escape. This review focuses on the latest research advances in heterogeneous subpopulations of CAFs within the breast cancer microenvironment, delves into how the complex bidirectional crosstalk between different CAF subpopulations and immune cells collaboratively shapes the tumor immune microenvironment (TIME), and summarizes various CAF-based therapeutic strategies for breast cancer, aiming to provide critical theoretical basis and novel therapeutic perspectives for the clinical translation of CAF heterogeneity research.

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来源期刊
CiteScore
18.20
自引率
1.80%
发文量
333
审稿时长
1 months
期刊介绍: The Journal of Experimental & Clinical Cancer Research is an esteemed peer-reviewed publication that focuses on cancer research, encompassing everything from fundamental discoveries to practical applications. We welcome submissions that showcase groundbreaking advancements in the field of cancer research, especially those that bridge the gap between laboratory findings and clinical implementation. Our goal is to foster a deeper understanding of cancer, improve prevention and detection strategies, facilitate accurate diagnosis, and enhance treatment options. We are particularly interested in manuscripts that shed light on the mechanisms behind the development and progression of cancer, including metastasis. Additionally, we encourage submissions that explore molecular alterations or biomarkers that can help predict the efficacy of different treatments or identify drug resistance. Translational research related to targeted therapies, personalized medicine, tumor immunotherapy, and innovative approaches applicable to clinical investigations are also of great interest to us. We provide a platform for the dissemination of large-scale molecular characterizations of human tumors and encourage researchers to share their insights, discoveries, and methodologies with the wider scientific community. By publishing high-quality research articles, reviews, and commentaries, the Journal of Experimental & Clinical Cancer Research strives to contribute to the continuous improvement of cancer care and make a meaningful impact on patients' lives.
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