癌症治疗的新时代:靶向蛋白酶体- bcl -2轴。

IF 12.8 1区 医学 Q1 ONCOLOGY
Sourabh Soni, Vandana Anang, Yutong Zhao, Jeffrey C Horowitz, Richard S Nho, Yohannes A Mebratu
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引用次数: 0

摘要

b细胞淋巴瘤-2 (Bcl-2)家族蛋白是细胞凋亡的关键调节因子,在癌症中经常失调,使细胞存活和凋亡的平衡倾向于存活。泛素-蛋白酶体系统(UPS)是通过调节蛋白质稳定性来控制Bcl-2水平的关键细胞机制。这篇综述深入研究了蛋白酶体和Bcl-2家族成员之间复杂的相互作用,探讨了蛋白酶体介导的降解如何影响细胞存活和增殖,从而影响癌症的进展。我们讨论了靶向蛋白酶体- bcl -2轴的治疗潜力,包括蛋白酶体抑制剂作为抗癌药物的使用。我们研究了它们的作用机制、临床疗效和局限性,同时探索了克服这些挑战的新策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis.

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis.

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis.

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis.

The B-cell lymphoma-2 (Bcl-2) family proteins, key regulators of apoptosis, are frequently dysregulated in cancer, tipping the balance of cell survival and apoptosis in favor of survival. The ubiquitin-proteasome system (UPS) is a critical cellular machinery that controls the Bcl-2 levels through regulation of protein stability. This review delves into the intricate interplay between the proteasome and Bcl-2 family members, exploring how proteasome-mediated degradation impacts cell survival and proliferation to influence cancer progression. We discuss the therapeutic potential of targeting the proteasome-Bcl-2 axis, including the use of proteasome inhibitors as anticancer agents. We examine their mechanisms of action, clinical efficacy, and limitations while exploring emerging strategies to overcome these challenges.

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来源期刊
CiteScore
18.20
自引率
1.80%
发文量
333
审稿时长
1 months
期刊介绍: The Journal of Experimental & Clinical Cancer Research is an esteemed peer-reviewed publication that focuses on cancer research, encompassing everything from fundamental discoveries to practical applications. We welcome submissions that showcase groundbreaking advancements in the field of cancer research, especially those that bridge the gap between laboratory findings and clinical implementation. Our goal is to foster a deeper understanding of cancer, improve prevention and detection strategies, facilitate accurate diagnosis, and enhance treatment options. We are particularly interested in manuscripts that shed light on the mechanisms behind the development and progression of cancer, including metastasis. Additionally, we encourage submissions that explore molecular alterations or biomarkers that can help predict the efficacy of different treatments or identify drug resistance. Translational research related to targeted therapies, personalized medicine, tumor immunotherapy, and innovative approaches applicable to clinical investigations are also of great interest to us. We provide a platform for the dissemination of large-scale molecular characterizations of human tumors and encourage researchers to share their insights, discoveries, and methodologies with the wider scientific community. By publishing high-quality research articles, reviews, and commentaries, the Journal of Experimental & Clinical Cancer Research strives to contribute to the continuous improvement of cancer care and make a meaningful impact on patients' lives.
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