Lina Hult, David Kylhammar, Jan Engvall, Carl Johan Östgren, Fredrik Nyström, Peter Blomstrand, Kristofer Hedman
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Pathological PSS was defined as a post-systolic index > 5% and was calculated as follows: [(maximum longitudinal strain - peak systolic longitudinal strain)/(maximum longitudinal strain)]. The endpoint was any MACE, defined as hospitalization or death due to heart failure, myocardial infarction, or stroke. Cox proportional hazard ratios (HR) with 95% confidence intervals (CI) were calculated and adjusted for sex, age, body mass index, hypertension, smoking, previous cardiovascular events, and HbA1c level. The mean follow-up time was 11.2 ± 2.3 years.</p><p><strong>Results: </strong>Pathological PSS was associated with an increased risk of MACEs after adjustment for other cardiovascular risk factors (HR 2.20, 95% CI 1.11-4.37). Subjects with reduced GLS, PSS and GLS combined in a risk prediction model, had an adjusted HR for MACEs of 2.94 (95% CI 1.33-6.52).</p><p><strong>Conclusions: </strong>Our results suggest that PSS may provide additional prognostic information for patients with T2D when used alone or in combination with GLS.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"12 1","pages":"21"},"PeriodicalIF":2.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400764/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pathological post-systolic shortening as a prognostic marker for major cardiovascular events in patients with type 2 diabetes.\",\"authors\":\"Lina Hult, David Kylhammar, Jan Engvall, Carl Johan Östgren, Fredrik Nyström, Peter Blomstrand, Kristofer Hedman\",\"doi\":\"10.1186/s44156-025-00085-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Post-systolic shortening (PSS) has emerged as a method for evaluating left ventricular dysfunction. 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引用次数: 0
摘要
背景:收缩后缩短(PSS)已成为评估左心室功能障碍的一种方法。我们的目的是确定病理性PSS单独或联合全局纵向应变(GLS)是否是2型糖尿病患者主要不良心血管事件(mace)的预后因素。在CARDIPP研究中,我们前瞻性地调查了364例55-65岁的2型糖尿病患者。所有患者在2005年至2009年间接受了超声心动图检查。PSS,通过斑点跟踪超声心动图测量,定义为主动脉瓣关闭后心肌收缩。病理PSS定义为收缩期后指数>.5 %,计算公式为[(最大纵向应变-收缩期峰值纵向应变)/(最大纵向应变)]。终点是任何MACE,定义为因心力衰竭、心肌梗死或中风而住院或死亡。计算Cox比例风险比(HR)和95%可信区间(CI),并根据性别、年龄、体重指数、高血压、吸烟、既往心血管事件和HbA1c水平进行调整。平均随访时间11.2±2.3年。结果:校正其他心血管危险因素后,病理性PSS与mace风险增加相关(HR 2.20, 95% CI 1.11-4.37)。在风险预测模型中,GLS降低、PSS和GLS合并的受试者,mace的调整HR为2.94 (95% CI 1.33-6.52)。结论:我们的研究结果表明,PSS可为T2D患者单独使用或与GLS联合使用提供额外的预后信息。
Pathological post-systolic shortening as a prognostic marker for major cardiovascular events in patients with type 2 diabetes.
Background: Post-systolic shortening (PSS) has emerged as a method for evaluating left ventricular dysfunction. We aimed to determine whether pathological PSS, alone or in combination with global longitudinal strain (GLS), is a prognostic factor for major adverse cardiovascular events (MACEs) in patients with type 2 diabetes. We prospectively investigated 364 patients with type 2 diabetes aged 55-65 years in the CARDIPP study. All patients underwent echocardiography between 2005 and 2009. PSS, measured by speckle tracking echocardiography, was defined as myocardial contraction after aortic valve closure. Pathological PSS was defined as a post-systolic index > 5% and was calculated as follows: [(maximum longitudinal strain - peak systolic longitudinal strain)/(maximum longitudinal strain)]. The endpoint was any MACE, defined as hospitalization or death due to heart failure, myocardial infarction, or stroke. Cox proportional hazard ratios (HR) with 95% confidence intervals (CI) were calculated and adjusted for sex, age, body mass index, hypertension, smoking, previous cardiovascular events, and HbA1c level. The mean follow-up time was 11.2 ± 2.3 years.
Results: Pathological PSS was associated with an increased risk of MACEs after adjustment for other cardiovascular risk factors (HR 2.20, 95% CI 1.11-4.37). Subjects with reduced GLS, PSS and GLS combined in a risk prediction model, had an adjusted HR for MACEs of 2.94 (95% CI 1.33-6.52).
Conclusions: Our results suggest that PSS may provide additional prognostic information for patients with T2D when used alone or in combination with GLS.
期刊介绍:
Echo Research and Practice aims to be the premier international journal for physicians, sonographers, nurses and other allied health professionals practising echocardiography and other cardiac imaging modalities. This open-access journal publishes quality clinical and basic research, reviews, videos, education materials and selected high-interest case reports and videos across all echocardiography modalities and disciplines, including paediatrics, anaesthetics, general practice, acute medicine and intensive care. Multi-modality studies primarily featuring the use of cardiac ultrasound in clinical practice, in association with Cardiac Computed Tomography, Cardiovascular Magnetic Resonance or Nuclear Cardiology are of interest. Topics include, but are not limited to: 2D echocardiography 3D echocardiography Comparative imaging techniques – CCT, CMR and Nuclear Cardiology Congenital heart disease, including foetal echocardiography Contrast echocardiography Critical care echocardiography Deformation imaging Doppler echocardiography Interventional echocardiography Intracardiac echocardiography Intraoperative echocardiography Prosthetic valves Stress echocardiography Technical innovations Transoesophageal echocardiography Valve disease.