【马里巴韦有效治疗3例异基因造血干细胞移植后感染人疱疹病毒6b的患者】。

Q3 Medicine
C W Jin, S Li, L X Wang, J Y Huang, X X Hu, Z L Zhang
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引用次数: 0

摘要

人疱疹病毒- 6b (HHV-6B)再激活是异基因造血干细胞移植(alloo - hsct)术后非复发死亡率的重要因素。本回顾性分析描述了三例同种异体造血干细胞移植后HHV-6B再激活的病例,所有这些病例在对氟甲酸钠一线抗病毒治疗失败或不耐受后,通过马里巴韦治疗实现了病毒清除。一名被诊断为HHV-6B脑炎的患者康复后无神经系统后遗症。未见药物不良反应。这些发现提供了初步证据,表明马里巴韦可以作为一种有效和安全的治疗接受同种异体造血干细胞移植患者HHV-6B再激活的补救性疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Maribavir effectively treated three patients with human herpesvirus-6B infection after allogeneic hematopoietic stem cell transplantation].

Human herpesvirus-6B (HHV-6B) reactivation is a significant contributor to nonrelapse mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This retrospective analysis describes three cases of HHV-6B reactivation following allo-HSCT, all of which achieved viral clearance with maribavir treatment following failure or intolerance to first-line antiviral therapy with foscarnet sodium. One patient diagnosed with HHV-6B encephalitis recovered without neurological sequelae. No adverse drug reactions to maribavir were observed. These findings provide preliminary evidence that maribavir may serve as an effective and safe salvage therapy for HHV-6B reactivation in patients receiving allo-HSCT.

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CiteScore
0.80
自引率
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发文量
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