氯菊酯破坏凡纳滨对虾的抗氧化防御反应。

IF 1.2 4区医学 Q4 PHARMACOLOGY & PHARMACY

Xenobiotica Pub Date : 2025-07-01 Epub Date: 2025-09-02 DOI:10.1080/00498254.2025.2538539

Juliana Righetto Moser, Eliziane Silva, Maria Risoleta Freire Marques

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引用次数: 0

摘要

氯菊酯是世界范围内常用的一种拟除虫菊酯，可能对水生环境产生影响，并对非目标生物产生毒理学影响。凡纳滨对虾（Litopenaeus vannamei）可以被包括在这些生物中，因为接触这种外源生物后，鳃和肝胰腺的酶促抗氧化防御反应被破坏。II期生物转化（谷胱甘肽s -转移酶- GST活性）和乙酰胆碱酯酶- AchE活性受到影响。II期生物转化（谷胱甘肽s -转移酶- GST活性）和乙酰胆碱酯酶- AchE活性均受到影响。

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Permethrin disrupts antioxidant defense responses in Litopenaeus vannamei.

Permethrin, a pyrethroid commonly used to grow crops worldwide, may affect the aquatic environment and show toxicological impact on non-target organisms.Farmed shrimp, Litopenaeus vannamei, can be included among these organisms since enzymatic antioxidant defense responses were disrupted in gills and hepatopancreas after exposure to this xenobiotic.Phase II biotransformation (Glutathione S-Transferase - GST activity) was affected as well as Acetylcholinesterase - AchE activity.Phase II biotransformation (Glutathione S-Transferase - GST activity) was affected as well as Acetylcholinesterase - AchE activity.1.

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来源期刊

Xenobiotica 医学-毒理学

CiteScore

3.80

自引率

5.60%

发文量

审稿时长

2 months

期刊介绍： Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology