不对称异硫原脲催化合成3,4-二氢吡喃的(4+2)环加成-3-乙酸乙酯与Michael受体。

IF 1.4 4区 化学 Q3 CHEMISTRY, ORGANIC
Synlett Pub Date : 2025-08-18 DOI:10.1055/a-2659-8340
Mario Hofer, Magdalena Piringer, Anna Scheucher, Lukas S Vogl, Mario Waser
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引用次数: 0

摘要

我们在此报道了使用3-乙酸乙酯作为C2构建块与各种迈克尔受体进行不对称(4+2)-杂环加成。使用手性异硫原脲作为路易斯碱催化剂,可以很好地控制这些反应的区域选择性、非对映选择性和对映选择性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Asymmetric Isochalcogenourea-Catalyzed Synthesis of 3,4-Dihydropyrans via (4+2)-Cycloadditions of Ethyl But-3-ynoate with Michael Acceptors.

We herein report the use of ethyl but-3-ynoate as a C2 building block for asymmetric (4+2)-heterocycloadditions with various Michael acceptors. Upon using chiral isochalcogenoureas as Lewis base catalysts, these reactions can be carried out with good to excellent control of the regioselectivity, diastereoselectivity, and enantioselectivity.

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来源期刊
Synlett
Synlett 化学-有机化学
CiteScore
3.40
自引率
5.00%
发文量
369
审稿时长
1 months
期刊介绍: SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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