Kaixin Lei, Zibing Zhao, Ao Chen, Xinqi An, Yupei Li, Baihai Su
{"title":"1990 - 2021年急性肾小球肾炎的全球负担和健康不平等：2021年全球负担疾病研究的系统分析","authors":"Kaixin Lei, Zibing Zhao, Ao Chen, Xinqi An, Yupei Li, Baihai Su","doi":"10.1080/0886022X.2025.2551731","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Acute glomerulonephritis (GN) is an acute episode of glomerular injury that affects both children and older adults. However, up-to-date data on its incidence, prevalence, mortality, and disability-adjusted life years (DALYs) remain limited. This study aims to provide the latest global trends and underlying health inequalities associated with acute GN.</p><p><strong>Methods: </strong>Incidence, prevalence, mortality, and DALYs per 100,000 population were reported at global, regional, and national levels, along with the Estimated Annual Percentage Change (EAPC). Global trends were analyzed by age, sex, and sociodemographic index (SDI), with forward projections estimated for the year 2040.</p><p><strong>Results: </strong>Globally, there were 528,368 (95% Uncertainty Interval [UI], 446,739 to 613,211) incident cases, 35,452 (95% UI, 30,151 to 41,655) prevalent cases, 10,761 (95% UI, 7,668 to 13,463) deaths, and 312,303 (95% UI, 208,981 to 393,514) DALYs attributed to acute GN in 2021. Children aged <14 years and older adults aged >85 years experienced the most severe burden. Frontier analysis revealed that middle SDI countries had the greatest potential to reduce the disease burden. Although the disease burden of acute GN has declined over the past three decades, our projections indicate that its incidence and prevalence will increase by 2040 due to population growth and aging.</p><p><strong>Conclusion: </strong>The global disease burden of acute GN has decreased; however, population growth and aging may be associated with rising incidence and prevalence by 2040. Middle SDI regions bear a disproportionate burden of acute GN, particularly among children and older adults.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2551731"},"PeriodicalIF":3.0000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404073/pdf/","citationCount":"0","resultStr":"{\"title\":\"Global burden and health inequalities of acute glomerulonephritis from 1990 to 2021: a systematic analysis of Global Burden Disease Study 2021.\",\"authors\":\"Kaixin Lei, Zibing Zhao, Ao Chen, Xinqi An, Yupei Li, Baihai Su\",\"doi\":\"10.1080/0886022X.2025.2551731\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Acute glomerulonephritis (GN) is an acute episode of glomerular injury that affects both children and older adults. However, up-to-date data on its incidence, prevalence, mortality, and disability-adjusted life years (DALYs) remain limited. This study aims to provide the latest global trends and underlying health inequalities associated with acute GN.</p><p><strong>Methods: </strong>Incidence, prevalence, mortality, and DALYs per 100,000 population were reported at global, regional, and national levels, along with the Estimated Annual Percentage Change (EAPC). Global trends were analyzed by age, sex, and sociodemographic index (SDI), with forward projections estimated for the year 2040.</p><p><strong>Results: </strong>Globally, there were 528,368 (95% Uncertainty Interval [UI], 446,739 to 613,211) incident cases, 35,452 (95% UI, 30,151 to 41,655) prevalent cases, 10,761 (95% UI, 7,668 to 13,463) deaths, and 312,303 (95% UI, 208,981 to 393,514) DALYs attributed to acute GN in 2021. Children aged <14 years and older adults aged >85 years experienced the most severe burden. Frontier analysis revealed that middle SDI countries had the greatest potential to reduce the disease burden. Although the disease burden of acute GN has declined over the past three decades, our projections indicate that its incidence and prevalence will increase by 2040 due to population growth and aging.</p><p><strong>Conclusion: </strong>The global disease burden of acute GN has decreased; however, population growth and aging may be associated with rising incidence and prevalence by 2040. Middle SDI regions bear a disproportionate burden of acute GN, particularly among children and older adults.</p>\",\"PeriodicalId\":20839,\"journal\":{\"name\":\"Renal Failure\",\"volume\":\"47 1\",\"pages\":\"2551731\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404073/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Renal Failure\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/0886022X.2025.2551731\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Renal Failure","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/0886022X.2025.2551731","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Global burden and health inequalities of acute glomerulonephritis from 1990 to 2021: a systematic analysis of Global Burden Disease Study 2021.
Background: Acute glomerulonephritis (GN) is an acute episode of glomerular injury that affects both children and older adults. However, up-to-date data on its incidence, prevalence, mortality, and disability-adjusted life years (DALYs) remain limited. This study aims to provide the latest global trends and underlying health inequalities associated with acute GN.
Methods: Incidence, prevalence, mortality, and DALYs per 100,000 population were reported at global, regional, and national levels, along with the Estimated Annual Percentage Change (EAPC). Global trends were analyzed by age, sex, and sociodemographic index (SDI), with forward projections estimated for the year 2040.
Results: Globally, there were 528,368 (95% Uncertainty Interval [UI], 446,739 to 613,211) incident cases, 35,452 (95% UI, 30,151 to 41,655) prevalent cases, 10,761 (95% UI, 7,668 to 13,463) deaths, and 312,303 (95% UI, 208,981 to 393,514) DALYs attributed to acute GN in 2021. Children aged <14 years and older adults aged >85 years experienced the most severe burden. Frontier analysis revealed that middle SDI countries had the greatest potential to reduce the disease burden. Although the disease burden of acute GN has declined over the past three decades, our projections indicate that its incidence and prevalence will increase by 2040 due to population growth and aging.
Conclusion: The global disease burden of acute GN has decreased; however, population growth and aging may be associated with rising incidence and prevalence by 2040. Middle SDI regions bear a disproportionate burden of acute GN, particularly among children and older adults.
期刊介绍：
Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
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