Sophie Wuyckens, Macarena Chocan Vera, Rasmus Nilsson, Viktor Wase, Dario Di Perri, Xavier Geets, John A Lee, Edmond Sterpin
{"title":"激活flash的质子SBRT治疗一个具有挑战性的脊柱转移病例。","authors":"Sophie Wuyckens, Macarena Chocan Vera, Rasmus Nilsson, Viktor Wase, Dario Di Perri, Xavier Geets, John A Lee, Edmond Sterpin","doi":"10.1088/1361-6560/ae023c","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective</i>. The FLASH effect, characterized by potential sparing of organs at risk (OARs) through ultra-high dose rate (DR) irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional DRs with hypofractionated schemes. While considerable biological research is needed to understand the FLASH effect and determine the FLASH modifying factors (FMF) for individual OARs, treatment planning studies have also emerged. This study evaluates the feasibility of achieving FLASH conditions in proton stereotactic body radiotherapy for spine metastases and establishes the required FMFs under different fractionation regimens.<i>Approach</i>. A conformal FLASH Proton SBRT plan was generated for a patient with spine metastasis in a research version of RayStation11B (RaySearch laboratories AB, Stockholm) on an IBA Proteus Plus system. Two oblique posterior beams were used in the plan. The prescribed dose to the CTV was set according to 3 different fractionation regimens: 5 fractions (fx) of 7 Gy, 8 fx of 5 Gy, and 10 fx of 4.2 Gy. Spot filtering and sorting techniques were applied to maximize the 5% pencil beam scanning DR in the spinal cord (SC). The FLASH effect was assumed to be observed within irradiated regions above 40 Gy s<sup>-1</sup>and 4 Gy per fraction.<i>Main results</i>. The generated plans successfully ensure robust target coverage in each fraction. The volume of SC that does not comply with the clinical goal adheres to the FLASH effect conditions in each fraction. Depending on the aforementioned fractionation schemes used, a FMF of approximately 0.6 to 0.8 is necessary to enable such treatment in FLASH conditions.<i>Significance</i>. This study indicates that treating challenging spine metastases with protons using FLASH delivery is technically feasible. However, clinical viability depends on optimistic parameters to trigger the FLASH effect and FMF values below 0.8, which are not yet guaranteed given current research.</p>","PeriodicalId":20185,"journal":{"name":"Physics in medicine and biology","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"FLASH-enabled proton SBRT for a challenging case of spine metastasis.\",\"authors\":\"Sophie Wuyckens, Macarena Chocan Vera, Rasmus Nilsson, Viktor Wase, Dario Di Perri, Xavier Geets, John A Lee, Edmond Sterpin\",\"doi\":\"10.1088/1361-6560/ae023c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objective</i>. The FLASH effect, characterized by potential sparing of organs at risk (OARs) through ultra-high dose rate (DR) irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional DRs with hypofractionated schemes. While considerable biological research is needed to understand the FLASH effect and determine the FLASH modifying factors (FMF) for individual OARs, treatment planning studies have also emerged. This study evaluates the feasibility of achieving FLASH conditions in proton stereotactic body radiotherapy for spine metastases and establishes the required FMFs under different fractionation regimens.<i>Approach</i>. A conformal FLASH Proton SBRT plan was generated for a patient with spine metastasis in a research version of RayStation11B (RaySearch laboratories AB, Stockholm) on an IBA Proteus Plus system. Two oblique posterior beams were used in the plan. The prescribed dose to the CTV was set according to 3 different fractionation regimens: 5 fractions (fx) of 7 Gy, 8 fx of 5 Gy, and 10 fx of 4.2 Gy. Spot filtering and sorting techniques were applied to maximize the 5% pencil beam scanning DR in the spinal cord (SC). The FLASH effect was assumed to be observed within irradiated regions above 40 Gy s<sup>-1</sup>and 4 Gy per fraction.<i>Main results</i>. The generated plans successfully ensure robust target coverage in each fraction. The volume of SC that does not comply with the clinical goal adheres to the FLASH effect conditions in each fraction. Depending on the aforementioned fractionation schemes used, a FMF of approximately 0.6 to 0.8 is necessary to enable such treatment in FLASH conditions.<i>Significance</i>. This study indicates that treating challenging spine metastases with protons using FLASH delivery is technically feasible. However, clinical viability depends on optimistic parameters to trigger the FLASH effect and FMF values below 0.8, which are not yet guaranteed given current research.</p>\",\"PeriodicalId\":20185,\"journal\":{\"name\":\"Physics in medicine and biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics in medicine and biology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6560/ae023c\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics in medicine and biology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6560/ae023c","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
FLASH-enabled proton SBRT for a challenging case of spine metastasis.
Objective. The FLASH effect, characterized by potential sparing of organs at risk (OARs) through ultra-high dose rate (DR) irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional DRs with hypofractionated schemes. While considerable biological research is needed to understand the FLASH effect and determine the FLASH modifying factors (FMF) for individual OARs, treatment planning studies have also emerged. This study evaluates the feasibility of achieving FLASH conditions in proton stereotactic body radiotherapy for spine metastases and establishes the required FMFs under different fractionation regimens.Approach. A conformal FLASH Proton SBRT plan was generated for a patient with spine metastasis in a research version of RayStation11B (RaySearch laboratories AB, Stockholm) on an IBA Proteus Plus system. Two oblique posterior beams were used in the plan. The prescribed dose to the CTV was set according to 3 different fractionation regimens: 5 fractions (fx) of 7 Gy, 8 fx of 5 Gy, and 10 fx of 4.2 Gy. Spot filtering and sorting techniques were applied to maximize the 5% pencil beam scanning DR in the spinal cord (SC). The FLASH effect was assumed to be observed within irradiated regions above 40 Gy s-1and 4 Gy per fraction.Main results. The generated plans successfully ensure robust target coverage in each fraction. The volume of SC that does not comply with the clinical goal adheres to the FLASH effect conditions in each fraction. Depending on the aforementioned fractionation schemes used, a FMF of approximately 0.6 to 0.8 is necessary to enable such treatment in FLASH conditions.Significance. This study indicates that treating challenging spine metastases with protons using FLASH delivery is technically feasible. However, clinical viability depends on optimistic parameters to trigger the FLASH effect and FMF values below 0.8, which are not yet guaranteed given current research.
期刊介绍：
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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